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Titolo:
Central alpha(1)-adrenoceptors: Their role in the modulation of attention and memory formation
Autore:
Sirvio, J; MacDonald, E;
Indirizzi:
Univ Kuopio, Dept Pharmacol & Toxicol, FIN-70211 Kuopio, Finland Univ Kuopio Kuopio Finland FIN-70211 Toxicol, FIN-70211 Kuopio, Finland Univ Kuopio, AI Virtanen Inst, FIN-70211 Kuopio, Finland Univ Kuopio Kuopio Finland FIN-70211 nen Inst, FIN-70211 Kuopio, Finland Kuopio Univ Hosp, Dept Neurol, SF-70210 Kuopio, Finland Kuopio Univ Hosp Kuopio Finland SF-70210 eurol, SF-70210 Kuopio, Finland
Titolo Testata:
PHARMACOLOGY & THERAPEUTICS
fascicolo: 1, volume: 83, anno: 1999,
pagine: 49 - 65
SICI:
0163-7258(199907)83:1<49:CATRIT>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; EXCITATORY SYNAPTIC TRANSMISSION; DEFICIT HYPERACTIVITY DISORDER; CORTICAL COGNITIVE FUNCTION; VENTRAL TEGMENTAL AREA; IN-SITU HYBRIDIZATION; ADULT-RAT BRAIN; ALPHA-1-ADRENERGIC RECEPTOR; CEREBRAL-CORTEX; ADRENERGIC-RECEPTORS;
Keywords:
alpha-adrenoceptors; noradrenaline; long-term potentiation; learning and memory; cognitive functions; arousal;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
161
Recensione:
Indirizzi per estratti:
Indirizzo: MacDonald, E Univ Kuopio, Dept Pharmacol & Toxicol, FIN-70211 Kuopio, Finland Univ Kuopio Kuopio Finland FIN-70211 -70211 Kuopio, Finland
Citazione:
J. Sirvio e E. MacDonald, "Central alpha(1)-adrenoceptors: Their role in the modulation of attention and memory formation", PHARM THERA, 83(1), 1999, pp. 49-65

Abstract

Adrenoceptors presently are classified into three main subclasses: alpha(1)-, alpha(2)-, and beta-receptors, each with three (perhaps more) subtypes. All three alpha(1)-adrenoceptor subtypes are present in rat brain. The purpose of this review is to assess the role of alpha(1)-adrenoceptors in the modulation of synaptic transmission and plasticity, as well as their ability to modulate higher cerebral functions, such as attentional and memory processes. However, since there are no truly subtype-specific agonists or antagonists available at present, it is virtually impossible to allocate a particular central effect to one or other of the subtypes. The activation of alpha(1)-adrenoceptors reduces the firing probability and glutamate release in the cornu ammonis of the hippocampus, alpha(1)-Adrenoceptors may flexiblymodulate weak and strong activation of the pyramidal neurones in the neocortex. alpha(1)-Adrenoceptors play only a minor role in the modulation of long-term potentiation in the hippocampus, and may influence many brain functions also via non-neuronal mechanisms, since glial cells can express alpha(1)-adrenoceptors. At the behavioural level, the activation of alpha(1)-adrenoceptors promotes vigilance and influences working memory and behavioural activation, while having only a minor role in the modulation of long-term memory. (C) 1999 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 03:31:32