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Titolo:
Altered cholinergic function in the basal forebrain of girls with Rett syndrome
Autore:
Wenk, GL; Hauss-Wegrzyniak, B;
Indirizzi:
Univ Arizona, Div Neural Syst Memory & Aging, Arizona Res Labs, Tucson, AZ85724 USA Univ Arizona Tucson AZ USA 85724 g, Arizona Res Labs, Tucson, AZ85724 USA
Titolo Testata:
NEUROPEDIATRICS
fascicolo: 3, volume: 30, anno: 1999,
pagine: 125 - 129
SICI:
0174-304X(199906)30:3<125:ACFITB>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVE GROWTH-FACTOR; ACETYLTRANSFERASE ACTIVITY; CEREBROSPINAL-FLUID; DNA FRAGMENTATION; SUBSTANTIA-NIGRA; NUCLEUS BASALIS; CELL-DEATH; APOPTOSIS; NEURONS; DISEASE;
Keywords:
Rett syndrome; acetylcholine; ChAT-positive neurons; nerve growth factor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Wenk, GL Univ Arizona, Div Neural Syst, 384 Life Sci N Bldg, Tucson, AZ 85724 USA Univ Arizona 384 Life Sci N Bldg Tucson AZ USA 85724 AZ 85724 USA
Citazione:
G.L. Wenk e B. Hauss-Wegrzyniak, "Altered cholinergic function in the basal forebrain of girls with Rett syndrome", NEUROPEDIAT, 30(3), 1999, pp. 125-129

Abstract

Rett syndrome (RS) is a neurodevelopmental disorder that is predominant infemales and is associated with cortical atrophy, stereotyped hand movements and severe mental deficiency. Previous studies have demonstrated a significant decline in number of choline acetyltransferase (ChAT)-containing neurons throughout the forebrain of RS girls. The loss of these ChAT-positive cells may be caused by a lack of nerve growth factor (NGF). In the current study, cortical levels of NGF were normal in RS girls as compared to age- and sex-matched controls. The number of neurons within the basal forebrain that express the 75 kDa (p75) low-affinity receptor for NGF was unchanged. Incontrast. the number of ChAT-positive neurons was significantly decreased. The results suggest that normal amounts of NGF are available for binding to the p75 receptor and for retrograde transport to forebrain cholinergic cells. however, these neurons do not respond by producing the ChAT protein that is necessary for the production of the neurotransmitter acetylcholine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 06:27:41