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Titolo:
Contribution of brain 99mTc-sestamibi SPECT for the differential diagnosisof tumoral recurrence and radionecrosis of subtentorial glial tumors in adults
Autore:
Lamy-Lhullier, C; Dubois, F; Blond, S; Lecouffe, P; Steinling, M;
Indirizzi:
CHRU, Clin Neurochirurg, Lille, France CHRU Lille FranceCHRU, Clin Neurochirurg, Lille, France
Titolo Testata:
NEUROCHIRURGIE
fascicolo: 2, volume: 45, anno: 1999,
pagine: 110 - 117
SICI:
0028-3770(199905)45:2<110:COB9SF>2.0.ZU;2-1
Fonte:
ISI
Lingua:
FRE
Soggetto:
POSITRON EMISSION TOMOGRAPHY; CEREBRAL RADIATION NECROSIS; F-18 FLUORODEOXYGLUCOSE; TL-201 SPECT; TC-99M SESTAMIBI; P-GLYCOPROTEIN; GLIOMAS; GRADE; PET; LESIONS;
Keywords:
SPECT; recurrence glioma; radionecrosis; Tc-99m Sestamibi;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Lamy-Lhullier, C CH Germon & Gauthier, Serv Neurol & Explorat Fonctionnelles Neurol, BP 809, F-62408 Bethune, France CH Germon & Gauthier BP 809 Bethune France F-62408 rance
Citazione:
C. Lamy-Lhullier et al., "Contribution of brain 99mTc-sestamibi SPECT for the differential diagnosisof tumoral recurrence and radionecrosis of subtentorial glial tumors in adults", NEUROCHIRE, 45(2), 1999, pp. 110-117

Abstract

CT scan and MR imaging are plot always reliable in the differential diagnosis between radionecrosis and recurrence of brain tumor. We describe the results of a prospective study using Tc-99m Sestamibi. 22 patients were included The histology of the tumor was astrocytoma (grade 2-4) oligodendroglioma (grade 2-3) or mixted (grade 2-3). SPECT was performedrising a Tomomatic 564, 1 h after the injection IV of 370 MBq of Tc-99m Sestamibi. Ten slices parallel to the orbitomeatal plane were obtained Two index were calculated i) CI: ratio of the mean counts in the lesion to the mean counts in the controlateral choroid plexus and ii) MI : ratio of the mean counts in the lesion to the controlateral mirror area The results were compared to stereotactic biopsies or to clinical course at 6 months. Twelve patients oat of 22 showed an increased uptake of the tracer and 11/12 presented with a recurrence. In 10 patients without fixation, 4 were false negative. The sensitivity SOP the detection of tumor recurrence was 73 % and specificity was 85 %. The positive predictive value was 91 % and the negative predictive value was 60 %. The use of a cut-off value superior to 2 for MI and superior to 0.5 for CI appears to be a good criterion for helping the diagnosis of relapse according to the analysis of Receiver Operating Characteristic curves (ROC). A positive SPECT was conclusive for the diagnosis of recurrence but a negative SPECT did not allow to assess the absence of recurrence. Limits of methods have to be stressed and searched for a better understanding of false negatives.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 23:58:13