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Titolo:
Volatile alkanes and increased concentrations of isoprene in exhaled air during hemodialysis
Autore:
Capodicasa, E; Trovarelli, G; De Medio, GE; Pelli, MA; Lippi, G; Verdura, C; Timio, M;
Indirizzi:
Univ Perugia, Monteluce Policlin, Ist Med Interna & Sci Oncol, I-06100 Perugia, Italy Univ Perugia Perugia Italy I-06100 a & Sci Oncol, I-06100 Perugia, Italy Univ Perugia, Inst Med Chem & Biochem, I-06100 Perugia, Italy Univ Perugia Perugia Italy I-06100 hem & Biochem, I-06100 Perugia, Italy Univ Perugia, Dept Surg & Surg Emergencies, I-06100 Perugia, Italy Univ Perugia Perugia Italy I-06100 g Emergencies, I-06100 Perugia, Italy San Giovanni Battista Gen Hosp, Nephrol & Dialysis Unit, Foligno, Italy San Giovanni Battista Gen Hosp Foligno Italy lysis Unit, Foligno, Italy
Titolo Testata:
NEPHRON
fascicolo: 4, volume: 82, anno: 1999,
pagine: 331 - 337
SICI:
0028-2766(199908)82:4<331:VAAICO>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIPID-PEROXIDATION ABNORMALITIES; LOW-DENSITY LIPOPROTEINS; VITAMIN-E; FATTY-ACIDS; BREATH; MEMBRANE; BIOSYNTHESIS; HYDROCARBON; HUMANS; PLASMA;
Keywords:
alkanes; isoprene; breath test; hemodialysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Capodicasa, E Univ Perugia, Monteluce Policlin, Ist Med Interna & Sci Oncol, Via Brunamonti, I-06100 Perugia, Italy Univ Perugia Via Brunamonti Perugia Italy I-06100 ia, Italy
Citazione:
E. Capodicasa et al., "Volatile alkanes and increased concentrations of isoprene in exhaled air during hemodialysis", NEPHRON, 82(4), 1999, pp. 331-337

Abstract

In this study we examined breath volatile hydrocarbon concentrations in exhaled air of hemodialysis patients. We assessed both C-2-C-5 alkanes - among them ethane and pentane the production of which in man is essentially dueto the action free radicals exert on polyunsaturated fatty acids - and isoprene, an unsaturated hydrocarbon the biosynthesis and biological effects of which are the subject of controversy and mounting interest. Twenty patients were studied. Evaluation was performed intrapatient in the breath of patients with chronic renal failure, before and after dialysis (20 patients) and, in the same cases, during hemodialytic treatment (10 patients). Breath concentrations of these volatile hydrocarbons, determined before dialysis, were not different from those of normal subjects. Dialysis did not modify the levels of the C2-C5 saturated hydrocarbons ethane, propane, butane and pentane. Instead, there was a marked increase in isoprene in all patients (basal values rose by a mean of 270%). Since isoprene was not present in the fluids or filters used for dialysis and there were only traces in the ambient air, the isoprene must have been produced endogenously during hemodialysis. As no situation has previously been reported to increase endogenous production of isoprene in humans, patients in hemodialysis offer a unique opportunity to investigate in depth the medical, biological and toxicological aspects of isoprene.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/10/20 alle ore 00:40:13