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Titolo:
Biological markers in body fluids for activity and progression in multiplesclerosis
Autore:
Sorensen, PS;
Indirizzi:
Copenhagen Univ Hosp, MS Res Unit, Ctr Neurosci, Rigshosp, DK-2100 Copenhagen, Denmark Copenhagen Univ Hosp Copenhagen Denmark DK-2100 2100 Copenhagen, Denmark
Titolo Testata:
MULTIPLE SCLEROSIS
fascicolo: 4, volume: 5, anno: 1999,
pagine: 287 - 290
SICI:
1352-4585(199908)5:4<287:BMIBFF>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
CIRCULATING ADHESION MOLECULES; PLACEBO-CONTROLLED TRIAL; MYELIN BASIC-PROTEIN; CEREBROSPINAL-FLUID; DISEASE-ACTIVITY; MRI ACTIVITY; MATRIX METALLOPROTEINASE-9; INTERFERON BETA-1B; SERIAL ANALYSIS; DISABILITY;
Keywords:
multiple sclerosis; biological markers; surrogate markers; disease activity; CSF (cerebrospinal fluid); blood; urine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Sorensen, PS Copenhagen Univ Hosp, MS Res Unit, Ctr Neurosci, Rigshosp, DK-2100 Copenhagen, Denmark Copenhagen Univ Hosp Copenhagen Denmark DK-2100en, Denmark
Citazione:
P.S. Sorensen, "Biological markers in body fluids for activity and progression in multiplesclerosis", MULT SCLER, 5(4), 1999, pp. 287-290

Abstract

Reliable biological markers in body fluids for disease activity and progression are important for our understanding of the pathophysiology and therapeutic decisions in various subtypes of multiple sclerosis. Sampling from body fluids such as cerebrospinol fluid, blood, and urine constitutes the Problem that the local immuno-inflammatory process takes place in the central nervous system whereas the disease activity is only to some extent reflected in the systemic immune comportment Promising results have been obtained in studies of adhesion molecules, pm-inflammatory cytokines, co-stimulatory molecules and neopterin as markers of disease activity in relapsing-remitting multiple sclerosis. However, these results apply to groups of patients but not necessarily to individual patients. Currently no single body fluid marker is sufficiently correlated to disease activity to be used in the individual patient in monitoring disease activity, progression, or therapeutic effects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 07:24:15