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Titolo:
MRI in multiple sclerosis: correlation with expanded disability status scale (EDSS)
Autore:
Barkhof, F;
Indirizzi:
Free Univ Amsterdam Hosp, MS MRI Ctr, NL-1007 MB Amsterdam, Netherlands Free Univ Amsterdam Hosp Amsterdam Netherlands NL-1007 MB m, Netherlands Free Univ Amsterdam Hosp, Dept Radiol, NL-1007 MB Amsterdam, Netherlands Free Univ Amsterdam Hosp Amsterdam Netherlands NL-1007 MB m, Netherlands
Titolo Testata:
MULTIPLE SCLEROSIS
fascicolo: 4, volume: 5, anno: 1999,
pagine: 283 - 286
SICI:
1352-4585(199908)5:4<283:MIMSCW>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESONANCE-IMAGING FINDINGS; T1-WEIGHTED SPIN-ECHO; MAGNETIC-RESONANCE; HYPOINTENSE LESIONS; DISEASE PROGRESSION; BRAIN;
Keywords:
magnetic resonance imaging; multiple sclerosis; expanded disability status scale;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Barkhof, F Free Univ Amsterdam Hosp, MS MRI Ctr, POB 7057, NL-1007 MB Amsterdam, Netherlands Free Univ Amsterdam Hosp POB 7057 Amsterdam NetherlandsNL-1007 MB
Citazione:
F. Barkhof, "MRI in multiple sclerosis: correlation with expanded disability status scale (EDSS)", MULT SCLER, 5(4), 1999, pp. 283-286

Abstract

Magnetic resonance (MR) imaging is very sensitive in showing disseminated MS lesions. Subclinical MR progression occurs frequently, explaining why MRis now used to monitor treatment even without measurable consequences, of new MR lesions to the Patient at this moment In the light of this clinico-radiological paradox, the significance of MR in MS is discussed, particularly in relation with the expanded disability status scale (EDSS). Gadolinium-enhancing lesions correlate with the occurrence of relapses, CSF myelin breakdown products end, in patients with relapsing-remitting disease with higher EDSS. However, the predictive value of the frequency of enhancement for changes in EDSS is only weak. For conventional R-weighted MR imaging the cross-sectional correlation with EDSS varies between 0.15 and 0.60 and is limited mainly by the inherent lack of tissues specificity of R-weighted images. Both TI block holes and magnetisation transfer (MT) parameters show a better correlation with EDSS; it should be noted that lesions in which those abnormalities are found go through on initial phase of enhancement as well. For TI block holes, a correlation up to 0.81 has been reported for SP patients. Post-mortem studies show that black holes and low MT ratios are in vivo markers of axonal loss. Preliminary data indicate that progressive atrophy also correlates with progression on the EDSS scale. More should be learned about the fate of new MR lesion with regards to development of axonal loss, which at present is difficult to predict in the enhancing stage. The existence of escape mechanisms, including remyelination, make a simple correlation with EDSS extremely unlikely, and perhaps not even desirable. Nevertheless, while the clinical effect of a given new lesion may be difficult to ascertain, the absence of (new) MR lesions is prognostically favourable as will be the degree to which new lesions ore prevented by treatment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 19:35:20