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Titolo:
Induction of heme oxygenase produces load-independent cardioprotective effects in hypertensive rats
Autore:
Seki, T; Naruse, M; Naruse, K; Yoshimoto, T; Tanabe, A; Seki, M; Tago, K; Imaki, T; Demura, R; Demura, H;
Indirizzi:
Tokyo Womens Med Univ, Inst Clin Endocrinol, Dept Med, Shinjuku Ku, Tokyo 1628666, Japan Tokyo Womens Med Univ Tokyo Japan 1628666 njuku Ku, Tokyo 1628666, Japan
Titolo Testata:
LIFE SCIENCES
fascicolo: 10, volume: 65, anno: 1999,
pagine: 1077 - 1086
SICI:
0024-3205(19990730)65:10<1077:IOHOPL>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
NATRIURETIC PEPTIDE PRODUCTION; CARBON-MONOXIDE; CARDIAC-HYPERTROPHY; BLOOD-PRESSURE; MESSENGER-RNA; NITRIC-OXIDE; EXPRESSION; ACTIVATION; CDNA; HEART;
Keywords:
heme oxygenase; carbon monoxide; blood pressure; cardiac hypertrophy; brain natriuretic peptide; cyclic GMP; stroke-prone spontaneously hypertensive rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Seki, T Tokyo Womens Med Univ, Inst Clin Endocrinol, Dept Med, Shinjuku Ku, 8-1 Kawada Cho, Tokyo 1628666, Japan Tokyo Womens Med Univ 8-1 Kawada ChoTokyo Japan 1628666 6, Japan
Citazione:
T. Seki et al., "Induction of heme oxygenase produces load-independent cardioprotective effects in hypertensive rats", LIFE SCI, 65(10), 1999, pp. 1077-1086

Abstract

Although heme oxygenase (HO) has been suggested to be involved in the regulation of cardiovascular function through production of carbon monoxide (CO), the pathophysiological significance of HO in hypertensive organ damage remains unknown. We examined the effects of inducing HO-1 mRNA by stannous chloride (SnCl2) on cardiac hypertrophy in stroke-prone spontaneously hypertensive rats (SHR-SP/Izm). Chronic administration of SnCl2 resulted in a significant decrease in left ventricular (LV) weight/body weight ratio and LV brain natriuretic peptide (BNP) mRNA levels as a marker of cardiac hypertrophy and a significant increase in LV HO-1 mRNA levels and LV cGMP contents in SHR-SP/Izm, while there was no significant change in systemic blood pressure. These results provide the first evidence that induction of HO in the heart attenuates cardiac hypertrophy in load-independent mechanism in genetically hypertensive rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 15:15:11