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Titolo:
Reproducibility of repeated measures of endogenous dopamine competition with [C-11]raclopride in the human brain in response to methylphenidate
Autore:
Wang, GJ; Volkow, ND; Fowler, JS; Logan, J; Pappas, NR; Wong, CT; Hitzemann, RJ; Netusil, N;
Indirizzi:
Brookhaven Natl Lab, Dept Med, Upton, NY 11973 USA Brookhaven Natl Lab Upton NY USA 11973 Lab, Dept Med, Upton, NY 11973 USA Brookhaven Natl Lab, Dept Chem, Upton, NY 11973 USA Brookhaven Natl Lab Upton NY USA 11973 ab, Dept Chem, Upton, NY 11973 USA SUNY Stony Brook, Dept Radiol, Stony Brook, NY 11794 USA SUNY Stony BrookStony Brook NY USA 11794 diol, Stony Brook, NY 11794 USA SUNY Stony Brook, Dept Psychiat, Stony Brook, NY 11794 USA SUNY Stony Brook Stony Brook NY USA 11794 hiat, Stony Brook, NY 11794 USA Vet Affairs Med Ctr, Psychiat Serv, Northport, NY USA Vet Affairs Med CtrNorthport NY USA r, Psychiat Serv, Northport, NY USA
Titolo Testata:
JOURNAL OF NUCLEAR MEDICINE
fascicolo: 8, volume: 40, anno: 1999,
pagine: 1285 - 1291
SICI:
0161-5505(199908)40:8<1285:RORMOE>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; EARLY PARKINSONS-DISEASE; NAIVE SCHIZOPHRENIC-PATIENTS; D2 RECEPTOR STATUS; C-11 RACLOPRIDE; D-2 RECEPTORS; DEPENDENT SUBJECTS; STRIATAL D-2; PET; AGE;
Keywords:
[C-11]raclopride; methylphenidate; pharmacologic challenge; PET; reproducibility;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Wang, GJ Brookhaven Natl Lab, Dept Med, Upton, NY 11973 USA Brookhaven Natl Lab Upton NY USA 11973 Med, Upton, NY 11973 USA
Citazione:
G.J. Wang et al., "Reproducibility of repeated measures of endogenous dopamine competition with [C-11]raclopride in the human brain in response to methylphenidate", J NUCL MED, 40(8), 1999, pp. 1285-1291

Abstract

The measure of changes in synaptic dopamine (DA) concentration in responseto the psychostimulant drug methylphenidate (MP) has been used as an indicator of responsiveness of the DA system. The purpose of this study was to assess the reproducibility of these measures. Methods: Seven healthy subjects were scanned with PET and [C-11]raclopride twice in the same day: 7 min after placebo or methylphenidate (0.5 mg/kg) administration. In parallel we also measured the physiologic and behavioral responses to placebo and to methylphenidate. The same procedures were repeated 1-2 wk later to assess test-retest reproducibility. Results: Measures of plasma to brain transfer constant (K1), striatal distribution volume (DVstr) and DA D-2 receptor availability (Bmax/Kd), for the placebo condition were similar for the first (El)and second (E2) evaluations (Bmax/Kd, E1: 2.77 +/- 0.44; E2: 2.97 +/- 0.44). MP administration did not change K1, but it significantly decreased DVstr (E1: -25.9% +/- 8.7%, P less than or equal to 0.0002; E2: -20.7% +/- 11.7%, P less than or equal to 0.007) and Bmax/Kd (E1: -18.4% +/- 8.7%, P less than or equal to 0.002; E2: -13.4% +/- 9.2%, P less than or equal to 0.008), and the magnitude of these changes, though lower for E2, did not differ significantly MP increased pulse rate (E1: +64% +/- 43%, P less than or equal to 0.002; E2: +69% +/- 33%, P less than or equal to 0.001), systolic pressure (E1: +37% +/- 19%, P less than or equal to 0.0006; E2: +29% =/- 15%, Pless than or equal to 0.0009), self reports for drug effects (0: nothing to 10: extreme) of "rush" (E1: +8 +/- 3, P less than or equal to 0.0004; E2:+6 +/- 4, P less than or equal to 0.01) and "high" (E1: +8 +/- 3, P less than or equal to 0.0001, E2: +8 +/- 3, P less than or equal to 0.0003), anxiety (El: +5 +/- 4, P less than or equal to 0.02; E2: +4 +/- 4, P = 0.1) andrestlessness (E1: +4 +/- 4, P less than or equal to 0.04; E2: +4 +/- 5, P = 0.1). The magnitude of the cardiovascular and behavioral effects did not differ between El and E2. Conclusion: MP-induced changes in striatal DV andin Bmax/Kd, as well as the behavioral and cardiovascular effects, were reproducible with repeated administration.

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Documento generato il 25/01/20 alle ore 19:16:40