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Titolo:
Prognostic value of FDG PET imaging in malignant pleural mesothelioma
Autore:
Benard, F; Sterman, D; Smith, RJ; Kaiser, LR; Albelda, SM; Alavi, A;
Indirizzi:
Univ Penn, Med Ctr, Dept Radiol, Div Nucl Med, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Nucl Med, Philadelphia, PA 19104 USA Univ Penn, Med Ctr, Dept Med, Div Pulm & Crit Care, Philadelphia, PA 19104USA Univ Penn Philadelphia PA USA 19104 Crit Care, Philadelphia, PA 19104USA Univ Penn, Med Ctr, Dept Surg, Div Thorac Surg, Philadelphia, PA 19104 USAUniv Penn Philadelphia PA USA 19104 orac Surg, Philadelphia, PA 19104 USA
Titolo Testata:
JOURNAL OF NUCLEAR MEDICINE
fascicolo: 8, volume: 40, anno: 1999,
pagine: 1241 - 1245
SICI:
0161-5505(199908)40:8<1241:PVOFPI>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION-TOMOGRAPHY; INTRATUMORAL DISTRIBUTION; F-18 FLUORODEOXYGLUCOSE; POST-INJECTION; CANCER-CELLS; FLUORINE-18-FLUORODEOXYGLUCOSE; PREDICTION; ENZYMOLOGY; SURVIVAL; GLIOMA;
Keywords:
fluorodeoxyglucose; PET; mesothelioma; survival;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Alavi, A Hosp Univ Penn, Div Nucl Med, 3400 Spruce St, Philadelphia, PA 19104 USA Hosp Univ Penn 3400 Spruce St Philadelphia PA USA 19104 19104 USA
Citazione:
F. Benard et al., "Prognostic value of FDG PET imaging in malignant pleural mesothelioma", J NUCL MED, 40(8), 1999, pp. 1241-1245

Abstract

Despite several attempts at treating malignant pleural mesothelioma with various modalities, mortality remains high, with median survival between 12 and 18 mo. This disease may have a highly variable clinical course, with occasional long-term survivors. The purpose of this study was to assess whether tumor metabolic activity, as assessed by fluorodeoxyglucose (FDG) PET imaging, correlates inversely with survival. Methods: Twenty-eight patients with suspected mesothelioma underwent FDG PET scanning between September 1995 and May 1997. A diagnosis of mesothelioma was confirmed in 22. Fully corrected scans with attenuation correction of the entire chest were available in 17 patients with sufficient follow-up for survival analysis. Standardized uptake values (SUVs) were determined from the most active tumor site in each patient. Results: Seven patients died during follow-up, at a median period of 5.3 mo after FDG PET scanning. Follow-up information was available on the remaining 10 patients for a median period of 15.6 mo after the PET study. The mean SUV of the deceased patients was 6.6 +/- 2.9, compared with 3.2 +/- 1.6 among the combined survivors. The deceased patients had tumor SUVs that were highly correlated with duration of survival after the PET study (r = 0.87, P < 0.05). The cumulative survival estimate by the Kaplan-Meier product limit method was 0.17 at 12 mo for the patients with tumor SUVs greater than the median value and 0.86 for those with lower SUVs. The survival distribution of the high SUV group showed significantly shorter survivals compared with the low SUV group (P < 0.01). Conclusion: Patients with highly active mesotheliomas on FDG PET imaging have a poor prognosis. High FDGuptake in these tumors indicates shorter patient survival.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 09:14:40