Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Rat hippocampal neurons are critically involved in physiological improvement of memory processes induced by cholecystokinin-B receptor stimulation
Autore:
Sebret, A; Lena, I; Crete, D; Matsui, T; Roques, BP; Dauge, V;
Indirizzi:
CNRS, Dept Pharmacochim Mol & Struct, INSERM,U266,Unite Mixte Rech 8600, Unite Format & Rech Sci Pharmaceut & Biol, F-75270 Paris 06, France CNRS Paris France 06 ech Sci Pharmaceut & Biol, F-75270 Paris 06, France Kobe Univ, Sch Med, Dept Med, Div 3, Kobe, Hyogo 6500017, Japan Kobe UnivKobe Hyogo Japan 6500017 Med, Div 3, Kobe, Hyogo 6500017, Japan
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 16, volume: 19, anno: 1999,
pagine: 7230 - 7237
SICI:
0270-6474(19990815)19:16<7230:RHNACI>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
FREELY-MOVING RATS; NUCLEUS-ACCUMBENS; CCK RECEPTORS; AUTORADIOGRAPHIC LOCALIZATION; EXTRACELLULAR DOPAMINE; INCREASES DOPAMINE; PREFRONTAL CORTEX; MAZE TASKS; RELEASE; BRAIN;
Keywords:
cholecystokinin-B receptors; spatial memory; CA1; prelimbic-infralimbic cortex; CCK release; CCK-B receptor-deficient mice;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Dauge, V CNRS, Dept Pharmacochim Mol & Struct, INSERM,U266,Unite Mixte Rech 8600, Unite Format & Rech Sci Pharmaceut & Biol, 4 Ave Observ, F-75270 Paris 06, France CNRS 4 Ave Observ Paris France 06 serv, F-75270 Paris 06, France
Citazione:
A. Sebret et al., "Rat hippocampal neurons are critically involved in physiological improvement of memory processes induced by cholecystokinin-B receptor stimulation", J NEUROSC, 19(16), 1999, pp. 7230-7237

Abstract

The involvement in memory processes of the neuropeptide cholecystokinin (CCK) through its interaction with the CCK-B receptors was studied. The two-trial recognition memory task was used. Control animals showed recognition memory after a 2 hr time interval but not after a 6 hr time interval betweenthe two trials. The improving effect of a selective CCK-B agonist, BC 264,intraperitoneally administered (0.3 mu g/kg) in the retrieval phase of thetask (6 hr time interval), was also observed after its injection (1 pmol/0.5 mu l) in the dorsal subiculum/CA1 of the hippocampus but not in the caudate/putamen nucleus or in the prefrontal cortex of rats. The CCK-B antagonist L-365,260 injected (10 ng/0.5 mu l) into this region of the hippocampus abolished the improving effect of BC 264 injected intraperitoneally. Furthermore, L-365,260 injected in the hippocampus suppressed the recognition of the novel arm normally found in the controls (2 hr time interval) when it was injected before the acquisition or the retrieval phase of the task. In addition, an increase of the extracellular levels of CCK-like immunoreactivity in the hippocampus of rats during the acquisition and retention phase ofthe task was observed. Finally, CCK-B receptor-deficient mice have an impairment of performance in the memory task (2 hr time interval). Together, these results support the physiological involvement of the CCKergic system through its interaction with CCK-B receptors in the hippocampus to improve performance of rodents in the spatial recognition memory test.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 10:10:46