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Titolo:
Thyroid hormone regulates reelin and dab1 expression during brain development
Autore:
Alvarez-Dolado, M; Ruiz, M; Del Rio, JA; Alcantara, S; Burgaya, F; Sheldon, M; Nakajima, K; Bernal, J; Howell, BW; Curran, T; Soriano, E; Munoz, A;
Indirizzi:
Univ Autonoma Madrid, CSIC, Inst Invest Biomed Alberto Sols, Madrid 28029,Spain Univ Autonoma Madrid Madrid Spain 28029 Alberto Sols, Madrid 28029,Spain Univ Barcelona, Dept Anim & Plant Cell Biol, E-08028 Barcelona, Spain UnivBarcelona Barcelona Spain E-08028 ll Biol, E-08028 Barcelona, Spain St Jude Childrens Res Hosp, Dept Dev Neurobiol, Memphis, TN 38105 USA St Jude Childrens Res Hosp Memphis TN USA 38105 ol, Memphis, TN 38105 USA Jikei Univ, Sch Med, Inst DNA Med, Dept Mol Neurobiol,Minato ku, Tokyo 1058461, Japan Jikei Univ Tokyo Japan 1058461 Neurobiol,Minato ku, Tokyo 1058461, Japan Fred Hutchinson Canc Res Ctr, Seattle, WA 98109 USA Fred Hutchinson Canc Res Ctr Seattle WA USA 98109 , Seattle, WA 98109 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 16, volume: 19, anno: 1999,
pagine: 6979 - 6993
SICI:
0270-6474(19990815)19:16<6979:THRRAD>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
CAJAL-RETZIUS CELLS; AUDITORY CALLOSAL CONNECTIONS; MESSENGER-RNA EXPRESSION; NERVE GROWTH-FACTOR; RAT-BRAIN; CEREBRAL-CORTEX; NEONATAL-HYPOTHYROIDISM; ORGANOTYPIC CULTURES; LAMINAR ORGANIZATION; NEURONAL DEVELOPMENT;
Keywords:
reelin; dab1; thyroid hormone; neuronal migration; cortical lamination; brain development;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
82
Recensione:
Indirizzi per estratti:
Indirizzo: Munoz, A Univ Autonoma Madrid, CSIC, Inst Invest Biomed Alberto Sols, Arturo Duperier 4, Madrid 28029, Spain Univ Autonoma Madrid Arturo Duperier 4 Madrid Spain 28029 Spain
Citazione:
M. Alvarez-Dolado et al., "Thyroid hormone regulates reelin and dab1 expression during brain development", J NEUROSC, 19(16), 1999, pp. 6979-6993

Abstract

The reelin and dab1 genes are necessary for appropriate neuronal migrationand lamination during brain development. Since these processes are controlled by thyroid hormone, we studied the effect of thyroid hormone deprivation and administration on the expression of reelin and dab1. As shown by Northern analysis, in situ hybridization, and immunohistochemistry studies, hypothyroid rats expressed decreased levels of reelin RNA and protein during the perinatal period [embryonic day 18 (E18) and postnatal day 0 (P0)]. The effect was evident in Cajal-Retzius cells of cortex layer I, as well as in layers V/VI, hippocampus, and granular neurons of the cerebellum. Al later ages, however, Reelin was more abundant in the cortex, hippocampus, cerebellum, and olfactory bulb of hypothyroid rats (P5), and no differences were detected at P15. Conversely, Dab1 levels were higher at PO, and lower at P5 in hypothyroid animals. In line with these results, reelin RNA and protein levels were higher in cultured hippocampal, slices from PO control rats compared to those from hypothyroid animals. Significantly, thyroid-dependent regulation of reelin anddab1 was confirmed in vivo and in vitro by hormone treatment of hypothyroid rats and organotypic cultures, respectively. In both cases, thyroid hormone led to an increase in reelin expression. Our data suggest that the effects of thyroid hormone on neuronal migration may be in part mediated throughthe control of reelin and dab1 expression during brain ontogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 08:05:59