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Titolo:
Genetic engineering of dendritic cells to express immunosuppressive molecules (viral IL-10, TGF-beta, and CTLA4Ig)
Autore:
Lu, L; Lee, WC; Takayama, T; Qian, SG; Gambotto, A; Robbins, PD; Thomson, AW;
Indirizzi:
Univ Pittsburgh, Med Ctr, Thomas E Starzl Transplantat Inst, Pittsburgh, PA 15213 USA Univ Pittsburgh Pittsburgh PA USA 15213 at Inst, Pittsburgh, PA 15213 USA Univ Pittsburgh, Dept Surg, Pittsburgh, PA 15213 USA Univ Pittsburgh Pittsburgh PA USA 15213 pt Surg, Pittsburgh, PA 15213 USA Univ Pittsburgh, Dept Mol Genet & Biochem, Pittsburgh, PA 15213 USA Univ Pittsburgh Pittsburgh PA USA 15213 Biochem, Pittsburgh, PA 15213 USA
Titolo Testata:
JOURNAL OF LEUKOCYTE BIOLOGY
fascicolo: 2, volume: 66, anno: 1999,
pagine: 293 - 296
SICI:
0741-5400(199908)66:2<293:GEODCT>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIGEN-PRESENTING CELLS; CARDIAC ALLOGRAFT SURVIVAL; GROWTH-FACTOR-BETA; INTERLEUKIN-10 IL-10; T-CELLS; PROGENITORS; TOLERANCE; RESPONSES; APOPTOSIS; IMMUNITY;
Keywords:
gene therapy; immunosuppression;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Lu, L Univ Pittsburgh, Med Ctr, Thomas E Starzl Transplantat Inst, E1545 Biomed Sci Tower,200 Lothrop St, Pittsburgh, PA 15213 USA Univ Pittsburgh E1545 Biomed Sci Tower,200 Lothrop St Pittsburgh PA USA 15213
Citazione:
L. Lu et al., "Genetic engineering of dendritic cells to express immunosuppressive molecules (viral IL-10, TGF-beta, and CTLA4Ig)", J LEUK BIOL, 66(2), 1999, pp. 293-296

Abstract

There is growing evidence that, in addition to their role as initiators ofimmune responses, dendritic cells (DC) can exhibit tolerogenic properties. Immature DC deficient in cell surface costimulatory/accessory molecules can prolong organ and pancreatic islet allograft survival, whereas in vitro manipulation of DC by exposure to a variety of factors (e.g., viral interleukin-10; CTLA4Ig) can confer tolerogenic properties on these cells. Genetic engineering of DC to express immunosuppressive molecules is, in theory, an attractive approach to the therapy of allograft rejection and possibly, autoimmune disorders.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/08/20 alle ore 18:06:46