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Titolo:
Electromechanical characterization of acute experimental myocardial infarction
Autore:
Kornowski, R; Hong, MK; Shiran, A; Fuchs, S; Pierre, A; Collins, SD; Elahham, S; Leon, MB;
Indirizzi:
Washington Hosp Ctr, Cardiol Res Fdn, Dept Cardiol, Washington, DC 20010 USA Washington Hosp Ctr Washington DC USA 20010 iol, Washington, DC 20010 USA
Titolo Testata:
JOURNAL OF INVASIVE CARDIOLOGY
fascicolo: 6, volume: 11, anno: 1999,
pagine: 329 - 336
SICI:
1042-3931(199906)11:6<329:ECOAEM>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISCHEMIA; HEART; POTENTIALS; OCCLUSION;
Keywords:
electrophysiology; mapping; myocardial infarction; stunning;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Kornowski, R Washington Hosp Ctr, Cardiol Res Fdn, Dept Cardiol, 1100 Irving St NW,4B-1, Washington, DC 20010 USA Washington Hosp Ctr 1100 Irving St NW,4B-1 Washington DC USA 20010
Citazione:
R. Kornowski et al., "Electromechanical characterization of acute experimental myocardial infarction", J INVAS CAR, 11(6), 1999, pp. 329-336

Abstract

Objective. A new cardiac mapping system combines harmless magnetic field energy and tip-deflecting catheters (equipped with location sensors) to obtain realtime S-dimensional electromechanical maps of the left ventricle endocardial surface without using x-ray fluoroscopy. This experimental study assessed electromechanical changes during acute coronary occlusion and reperfusion in a canine model. Methods. Group 1 (n = 10) underwent coronary occlusion for 45 minutes followed by reperfusion (n = 6) and group 2 (n = 11) underwent coronary occlusion for 90 minutes. Endocardial peak-to-peak voltage amplitudes and local endocardial shortening values were measured in ischemic and non-ischemic zones at baseline, following coronary occlusion and reperfusion. Results. In ischemic zones, local shortening was significantly reduced during coronary occlusion compared to baseline (Group 1: 4.7 +/- 2.0% at 45 minutes vs. 15.5 +/- 3.4%, p < 0.001, 6.2 +/- 2.1% at 90 minutes vs. 15.5 +/-3.4%, p < 0.001; Group 2: 5.0 +/- 2.9% at 90 minutes vs. 13.9 +/- 3.3%, p = 0.007). Coronary occlusion caused a significant reduction in voltage potentials in the ischemic area (unipolar voltage at 45 minutes: 32.2 +/- 7.3 mV vs. 36.2 +/- 8.5 mV at baseline, p = 0.03; unipolar voltage at 90 minutes: 30.5 +/- 11.3 mV vs. 38.3 +/- 14.2 mV, p = 0.003; bipolar voltage at 45 minutes: 7.6 +/- 5.5 mV vs. 10.1 +/- 6.0 mV, p < 0.04; bipolar voltage at 90minutes: 7.6 +/- 4.4 mV vs. 9.8 +/- 6.2 mV, p < 0.02). Voltage amplitudes were no longer reduced during reperfusion (unipolar voltage: 34.3 +/- 10.5 mV vs. 36.2 +/- 8.5 mV, p = 0.26; bipolar voltage: 9.1 +/- 4.5 mV vs. 10.1 /- 6.0 mV at baseline, p = 0.37), or in non-ischemic regions during eithercoronary occlusion or reperfusion. Conclusions. Electromechanical mapping study provides unique insights intoacute myocardial infarction and stunning by detection and localization of early electromechanical changes during coronary occlusion and/or reperfusion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 11:01:16