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Titolo:
Phospho-LAT-independent activation of the Ras-mitogen-activated protein kinase pathway: A differential recruitment model of TCR partial agonist signaling
Autore:
Chan, LA; Madrenas, J;
Indirizzi:
John P Robarts Res Inst, Transplantat & Immunobiol Grp, London, ON N6A 5K8, Canada John P Robarts Res Inst London ON Canada N6A 5K8 ndon, ON N6A 5K8, Canada Univ Western Ontario, Dept Microbiol & Immunol, London, ON, Canada Univ Western Ontario London ON Canada biol & Immunol, London, ON, Canada Univ Western Ontario, Dept Med, London, ON, Canada Univ Western Ontario London ON Canada ario, Dept Med, London, ON, Canada
Titolo Testata:
JOURNAL OF IMMUNOLOGY
fascicolo: 4, volume: 163, anno: 1999,
pagine: 1853 - 1858
SICI:
0022-1767(19990815)163:4<1853:PAOTRP>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELL RECEPTOR; PHOSPHOTYROSINE-BINDING DOMAIN; ANTIGEN RECEPTOR; ZETA-CHAIN; GRB2-ASSOCIATED PROTEINS; TYROSINE KINASES; ZAP-70; SHC; PHOSPHORYLATION; SLP-76;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Madrenas, J John P Robarts Res Inst, Transplantat & Immunobiol Grp, Room 2-05,POB 5015,100 Perth Dr, London, ON N6A 5K8, Canada John P Robarts Res Inst Room 2-05,POB 5015,100 Perth Dr London ON Canada N6A 5K8
Citazione:
L.A. Chan e J. Madrenas, "Phospho-LAT-independent activation of the Ras-mitogen-activated protein kinase pathway: A differential recruitment model of TCR partial agonist signaling", J IMMUNOL, 163(4), 1999, pp. 1853-1858

Abstract

Stimulation of mature T cells with agonist ligands of the Ag receptor (TCR) causes rapid phosphorylation of tyrosine-based activation motifs in the intracellular portion of TCR-zeta and CD3 and activation of several intracellular signaling cascades. Coordinate activation of these pathways is dependent on Lck- and ZAP-70-mediated tyrosine phosphorylation of a 36-kDa linkerfor activation of T cells and subsequent recruitment of phospholipase C-gamma 1, Grb2-SOS, and SLP-76-vav, Here, we show that TCR partial agonist ligands can selectively activate one of these pathways, the Ras-mitogen-activated protein kinase pathway, by inducing recruitment of Grb2-SOS complexes to incompletely phosphorylated p21 phospho-TCR-zeta, This bypasses the need for activation of Lck and ZAP-70, and for phosphorylation of the linker foractivation of T cells to activate Pas, We propose a general model in whichdifferential recruitment of activating complexes away from transmembrane linker proteins may determine selective activation of a given signaling pathway.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 04:48:39