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Titolo:
Redundant role of the Syk protein tyrosine kinase in mouse NK cell differentiation
Autore:
Colucci, F; Turner, M; Schweighoffer, E; Guy-Grand, D; Di Bartolo, V; Salcedo, M; Tybulewicz, VLJ; Di Santo, JP;
Indirizzi:
Hop Necker Enfants Malad, INSERM, U429, F-75015 Paris, France Hop Necker Enfants Malad Paris France F-75015 429, F-75015 Paris, France Natl Inst Med Res, London NW7 1AA, England Natl Inst Med Res London England NW7 1AA ed Res, London NW7 1AA, England Inst Pasteur, Paris, France Inst Pasteur Paris FranceInst Pasteur, Paris, France
Titolo Testata:
JOURNAL OF IMMUNOLOGY
fascicolo: 4, volume: 163, anno: 1999,
pagine: 1769 - 1774
SICI:
0022-1767(19990815)163:4<1769:RROTSP>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
NATURAL-KILLER-CELLS; RECEPTOR-GAMMA-CHAIN; NK1.1(+) T-CELLS; MICE LACKING; THYMOCYTE DEVELOPMENT; SIGNAL-TRANSDUCTION; FCR-GAMMA; ZAP-70; ACTIVATION; EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Di Santo, JP Hop Necker Enfants Malad, INSERM, U429, 149 Rue Sevres, F-75015 Paris, France Hop Necker Enfants Malad 149 Rue Sevres Paris France F-75015
Citazione:
F. Colucci et al., "Redundant role of the Syk protein tyrosine kinase in mouse NK cell differentiation", J IMMUNOL, 163(4), 1999, pp. 1769-1774

Abstract

Syk and ZAP-70 subserve nonredundant functions in B and T lymphopoiesis. In the absence of Syk, B cell development is blocked, while T cell development is arrested in the absence of ZAP-70, The receptors and the signaling molecules required for differentiation of NK cells are poorly characterized. Here we investigate the role of the Syk protein tyrosine kinase in NK cell differentiation. Hemopoietic chimeras were generated by reconstituting alymphoid (B-, T-, NK-) recombinase-activating gene-2 x common cytokine receptor gamma-chain double-mutant mice with Syk(-/-) fetal liver cells. The phenotypically mature Syk(-/-) NK cells that developed in this context were fully competent in natural cytotoxicity and in calibrating functional inhibitory receptors for MHC molecules. Syk-deficient NK cells demonstrated reduced levels of Ab-dependent cellular cytotoxicity. Nevertheless, Syk(-/-) NK cells could signal through NK1.1 and 2B4 activating receptors and expressed ZAP-70 protein. We conclude that the Syk protein tyrosine kinase is not essential for murine NK cell development, and that compensatory signaling pathways (including those mediated through ZAP-70) may sustain most NK cell functions in the absence of Syk.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 16:05:13