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Titolo:
Elevated fasting insulin predicts incident hypertension: the ARIC study
Autore:
Liese, AD; Mayer-Davis, EJ; Chambless, LE; Folsom, AR; Sharrett, AR; Brancati, FL; Heiss, G;
Indirizzi:
Univ Munster, Inst Epidemiol & Social Med, D-48129 Munster, Germany Univ Munster Munster Germany D-48129 ocial Med, D-48129 Munster, Germany Univ S Carolina, Sch Publ Hlth, Dept Epidemiol & Biostat, Columbia, SC 29208 USA Univ S Carolina Columbia SC USA 29208 l & Biostat, Columbia, SC 29208 USA Univ N Carolina, Sch Publ Hlth, Dept Biostat, Chapel Hill, NC USA Univ N Carolina Chapel Hill NC USA th, Dept Biostat, Chapel Hill, NC USA Univ Minnesota, Sch Publ Hlth, Div Epidemiol, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 demiol, Minneapolis, MN 55455 USA NHLBI, NIH, DECA, Bethesda, MD 20892 USA NHLBI Bethesda MD USA 20892NHLBI, NIH, DECA, Bethesda, MD 20892 USA Johns Hopkins Med Inst, Welch Ctr Prevent Epidemiol & Clin Res, Baltimore,MD 21205 USA Johns Hopkins Med Inst Baltimore MD USA 21205 Res, Baltimore,MD 21205 USA Univ N Carolina, Sch Publ Hlth, Dept Epidemiol, Chapel Hill, NC USA Univ NCarolina Chapel Hill NC USA , Dept Epidemiol, Chapel Hill, NC USA
Titolo Testata:
JOURNAL OF HYPERTENSION
fascicolo: 8, volume: 17, anno: 1999,
pagine: 1169 - 1177
SICI:
0263-6352(199908)17:8<1169:EFIPIH>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH BLOOD-PRESSURE; SYNDROME SYNDROME-X; MIDDLE-AGED MEN; ATHEROSCLEROSIS RISK; RESISTANCE-SYNDROME; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; YOUNG-ADULTS; SHORT-TERM; BASE-LINE;
Keywords:
hypertension; insulin; insulin resistance; obesity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Liese, AD Univ Munster, Inst Epidemiol & Social Med, Domagkstr 3, D-48129 Munster, Germany Univ Munster Domagkstr 3 Munster Germany D-48129 nster, Germany
Citazione:
A.D. Liese et al., "Elevated fasting insulin predicts incident hypertension: the ARIC study", J HYPERTENS, 17(8), 1999, pp. 1169-1177

Abstract

Objective The prospective association of insulin and hypertension has beenunder debate in the context of the development of the insulin resistance or multiple metabolic syndrome. We examined the predictive associations of fasting serum insulin with incident hypertension occurring alone or as part of the multiple metabolic syndrome. Design Analyses were restricted to 5221 middle-aged participants of the Atherosclerosis Risk in Communities Study cohort who were free of component disorders of the multiple metabolic syndrome (hypertension; diabetes; high triglycerides and/or low HDL cholesterol (dyslipidaemias)) at baseline. Outcome A total of 1018 individuals developed hypertension, 801 in the absence of components of the metabolic syndrome and 217 in combination with diabetes or dyslipidaemias, between 1987 and 1993,Results Elevated fasting insulin (top quartile versus lowest quartile) wasassociated with overall incident hypertension in European Americans [hazard rate ratio (HRR) 2.0, 95% confidence interval (CI) 1.7-2.43 but the results were inconclusive in African Americans (HRR 1.3, 95% CI 0.9-1.8) after adjustment for age, gender and study centre. Among European Americans, body mass index and abdominal girth only partly explained the observed association. Elevated fasting insulin was more strongly predictive of hypertension occurring as a component of the multiple metabolic syndrome (HRR 2.4, 95% CI1.5-3.9) than of hypertension occurring alone (HRR 1.3, 95% CI 1.0-1.7) adjusting statistically for age, gender, study centre, body mass index and abdominal girth. Conclusions The results are consistent with the concept of an aetiologicalheterogeneity for hypertension and may explain previously reported inconsistent findings on the association of insulin with incident hypertension. I Hypertens 1999, 17:1169-1177 (C) Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 13:51:16