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Titolo:
Endothelial-monocyte activating polypeptide II, a novel antitumor cytokinethat suppresses primary and metastatic tumor growth and induces apoptosis in growing endothelial cells
Autore:
Schwarz, MA; Kandel, J; Brett, J; Li, J; Hayward, J; Schwarz, RE; Chappey, O; Wautier, JL; Chabot, J; Lo Gerfo, P; Stern, D;
Indirizzi:
Univ So Calif, Childrens Hosp Los Angeles, Dept Pediat, Los Angeles, CA 90027 USA Univ So Calif Los Angeles CA USA 90027 Pediat, Los Angeles, CA 90027 USA Univ So Calif, Childrens Hosp Los Angeles, Dept Surg, Los Angeles, CA 90027 USA Univ So Calif Los Angeles CA USA 90027 pt Surg, Los Angeles, CA 90027 USA Columbia Univ Coll Phys & Surg, Dept Pediat, New York, NY 10032 USA Columbia Univ Coll Phys & Surg New York NY USA 10032 w York, NY 10032 USA Columbia Univ Coll Phys & Surg, Dept Physiol, New York, NY 10032 USA Columbia Univ Coll Phys & Surg New York NY USA 10032 w York, NY 10032 USA Columbia Univ Coll Phys & Surg, Dept Surg, New York, NY 10032 USA ColumbiaUniv Coll Phys & Surg New York NY USA 10032 w York, NY 10032 USA Genentech Inc, S San Francisco, CA 94080 USA Genentech Inc S San Francisco CA USA 94080 S San Francisco, CA 94080 USA Mem Sloan Kettering Canc Ctr, Dept Surg, New York, NY 10021 USA Mem Sloan Kettering Canc Ctr New York NY USA 10021 New York, NY 10021 USA Univ Paris 07, Lab Rech Biol Vasc & Cellulaire, Unite Immunohematol, F-75475 Paris, France Univ Paris 07 Paris France F-75475 Immunohematol, F-75475 Paris, France
Titolo Testata:
JOURNAL OF EXPERIMENTAL MEDICINE
fascicolo: 3, volume: 190, anno: 1999,
pagine: 341 - 353
SICI:
0022-1007(19990802)190:3<341:EAPIAN>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECROSIS-FACTOR CACHECTIN; INDUCED ANGIOGENESIS; MONOCLONAL-ANTIBODY; BASEMENT-MEMBRANE; EXPRESSION; HYPOXIA; INDUCTION; DORMANCY; HEPARIN; CANCER;
Keywords:
tumor; capillary endothelium; programmed cell death; cell growth inhibitors; blood vessels;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Schwarz, MA Univ So Calif, Childrens Hosp Los Angeles, Dept Pediat, 4650 Sunset Blvd,MS 66, Los Angeles, CA 90027 USA Univ So Calif 4650 Sunset Blvd,MS 66 Los Angeles CA USA 90027
Citazione:
M.A. Schwarz et al., "Endothelial-monocyte activating polypeptide II, a novel antitumor cytokinethat suppresses primary and metastatic tumor growth and induces apoptosis in growing endothelial cells", J EXP MED, 190(3), 1999, pp. 341-353

Abstract

Neovascularization is essential for growth and spread of primary and metastatic tumors. We have identified a novel cytokine, endothelial-monocyte activating polypeptide (EMAP) II, that potently inhibits tumor growth, and appears to have antiangiogenic activity. Mice implanted with Matrigel showed an intense local angiogenic response, which EMAP II blocked by 76% (P < 0.001). Neovascularization of the mouse cornea was similarly prevented by EMAP II (P < 0.003). Intraperitoneally administered EMAP II suppressed the growth of primary Lewis lung carcinomas, with a reduction in tumor volume of 65%versus controls (P < 0.003). Tumors from human breast carcinoma-derived MDA-MB 468 cells were suppressed by >80% in EMAP II-treated animals (P < 0.005). In a lung metastasis model, EMAP II blocked outgrowth of Lewis lung carcinoma macrometastases; total surface metastases were diminished by 65%, and of the 35% metastases present, approximate to 80% were inhibited with maximum diameter <2 mm (P < 0.002 vs. controls). In growing capillary endothelial cultures, EMAP II induced apoptosis in a time- and dose dependent manner, whereas other cell types were unaffected. These data suggest that EMAP II is a tumor-suppressive mediator with antiangiogenic properties allowing it to target growing endothelium and limit establishment of neovasculature.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 22:23:11