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Titolo:
Regulation of E-cadherin: does hypoxia initiate the metastatic cascade?
Autore:
Beavon, IRG;
Indirizzi:
S African Inst Med Res, Sch Pathol, Dept Anat Pathol, ZA-2000 Johannesburg, South Africa S African Inst Med Res Johannesburg South Africa ZA-2000 g, South Africa Univ Witwatersrand, ZA-2000 Johannesburg, South Africa Univ WitwatersrandJohannesburg South Africa ZA-2000 sburg, South Africa
Titolo Testata:
JOURNAL OF CLINICAL PATHOLOGY-MOLECULAR PATHOLOGY
fascicolo: 4, volume: 52, anno: 1999,
pagine: 179 - 188
SICI:
1366-8714(199908)52:4<179:ROEDHI>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-CELL ADHESION; EPIDERMAL GROWTH-FACTOR; TYROSINE KINASE SUBSTRATE; ALPHA-CATENIN EXPRESSION; HUMAN GASTRIC CARCINOMAS; MOLECULE E-CADHERIN; MURINE TUMOR-CELLS; AUTOCRINE MOTILITY FACTOR; HUMAN ESOPHAGEAL CANCER; LYMPH-NODE METASTASES;
Keywords:
E-cadherin; cell adhesion; hypoxia; tumour necrosis;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
170
Recensione:
Indirizzi per estratti:
Indirizzo: Beavon, IRG S African Inst Med Res, Sch Pathol, Dept Anat Pathol, POB 1038, ZA-2000 Johannesburg, South Africa S African Inst Med Res POB 1038 Johannesburg South Africa ZA-2000
Citazione:
I.R.G. Beavon, "Regulation of E-cadherin: does hypoxia initiate the metastatic cascade?", J CL PATH-M, 52(4), 1999, pp. 179-188

Abstract

The ability of tumours to metastasise is regarded as one of the hallmarks of malignancy. The process through which tumours evolve to achieve this hasbeen termed the metastatic cascade. This cascade has been the subject of much investigation over many years. One of the vital events identified by these investigations is the reduction of adhesion between tumour cells facilitating invasion of the surrounding tissues and vascular channels, ultimately leading to the development of a distant metastasis. E-cadherin and its associated catenin complex have been identified as key molecules in cell adhesion. This review looks at the structure and interaction of the E-cadherin-catenin complex and the factors that appear to regulate E-cadherin expression and thus cell adhesion. From the data gathered, it has become possible to propose the hypothesis that the development of tumour hypoxia is the initiating factor that sets the tumour on the road to metastasis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/08/20 alle ore 23:26:04