Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The structure of human lipoprotein A-I - Evidence for the "belt" model"
Autore:
Koppaka, V; Silvestro, L; Engler, JA; Brouillette, CG; Axelsen, PH;
Indirizzi:
Univ Penn, Sch Med, Dept Pharmacol, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Pharmacol, Philadelphia, PA 19104 USA Univ Penn, Sch Med, Dept Med, Infect Dis Sect, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Dis Sect, Philadelphia, PA 19104 USA Univ Penn, Sch Med, Johnson Fdn Mol Biophys, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 l Biophys, Philadelphia, PA 19104 USA Univ Alabama, Med Ctr, Dept Biochem & Mol Genet, Birmingham, AL 35294 USA Univ Alabama Birmingham AL USA 35294 Mol Genet, Birmingham, AL 35294 USA Univ Alabama, Med Ctr, Dept Physiol Opt, Ctr Macromol Crystallog, Birmingham, AL 35294 USA Univ Alabama Birmingham AL USA 35294 Crystallog, Birmingham, AL 35294 USA
Titolo Testata:
JOURNAL OF BIOLOGICAL CHEMISTRY
fascicolo: 21, volume: 274, anno: 1999,
pagine: 14541 - 14544
SICI:
0021-9258(19990521)274:21<14541:TSOHLA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-DENSITY-LIPOPROTEIN; CORONARY HEART-DISEASE; LIPID-FREE STRUCTURE; INFRARED-SPECTROSCOPY; TERMINAL DELETIONS; CONFORMATION; FLUORESCENCE; MEMBRANES; RECEPTOR; GENE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Axelsen, PH Univ Penn, Sch Med, Dept Pharmacol, 3620 Hamilton Walk, Philadelphia, PA 19104 USA Univ Penn 3620 Hamilton Walk Philadelphia PA USA 19104104 USA
Citazione:
V. Koppaka et al., "The structure of human lipoprotein A-I - Evidence for the "belt" model"", J BIOL CHEM, 274(21), 1999, pp. 14541-14544

Abstract

The two main competing models for the structure of discoidal lipoprotein A-I complexes both presume that the protein component is helical and situated around the perimeter of a lipid bilayer disc. However, the more popular "picket fence" model orients the protein helices perpendicular to the surface of the lipid bilayer, while the alternative "belt" model orients them parallel to the bilayer surface. To distinguish between these models, we have investigated the structure of human lipoprotein A-I using a novel form of polarized internal reflection infrared spectroscopy that can characterize the relative orientation of protein and lipid components in the lipoprotein complexes under native conditions. Our results verify lipid bilayer structure in the complexes and point unambiguously to the belt model.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 12:40:58