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Titolo:
Results of proton therapy of uveal melanomas treated in Nice
Autore:
Courdi, A; Caujolle, JP; Grange, JD; Diallo-Rosier, L; Sahel, J; Bacin, F; Zur, C; Gastaud, P; Iborra-Brassart, N; Herault, J; Chauvel, P;
Indirizzi:
Ctr Antoine Lacassagne, F-06189 Nice 2, France Ctr Antoine Lacassagne Nice France 2 Lacassagne, F-06189 Nice 2, France St Roch Hosp, Nice, France St Roch Hosp Nice FranceSt Roch Hosp, Nice, France Hop Croix Rousse, F-69317 Lyon, France Hop Croix Rousse Lyon France F-69317 Croix Rousse, F-69317 Lyon, France Hop Pellegrin, F-33076 Bordeaux, France Hop Pellegrin Bordeaux France F-33076 ellegrin, F-33076 Bordeaux, France Hop Univ Strasbourg, Strasbourg, France Hop Univ Strasbourg Strasbourg France iv Strasbourg, Strasbourg, France CHRU, Clin Ophthalmol, Clermont Ferrand, France CHRU Clermont Ferrand France Clin Ophthalmol, Clermont Ferrand, France
Titolo Testata:
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
fascicolo: 1, volume: 45, anno: 1999,
pagine: 5 - 11
SICI:
0360-3016(19990801)45:1<5:ROPTOU>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
BEAM IRRADIATION; ENUCLEATION; MORTALITY; RATES;
Keywords:
proton therapy; uveal melanoma; eye tumors; treatment; cause-specific survival; prognostic factors; metastatic rate; local control; enucleation rate; complications; visual acuity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Courdi, A Ctr Antoine Lacassagne, 33 Ave Valombrose, F-06189 Nice 2, France Ctr Antoine Lacassagne 33 Ave Valombrose Nice France 2 , France
Citazione:
A. Courdi et al., "Results of proton therapy of uveal melanomas treated in Nice", INT J RAD O, 45(1), 1999, pp. 5-11

Abstract

Purpose: To present the first results of uveal melanomas treated with the Medicye Cyclotron 65 MeV proton beam facility in Nice, analyzing the factors that affect the cause-specific survival (CSS), metastatic rate, and reporting the visual outcome. Methods and Materials: This study concerns 538 patients referred by Frenchinstitutions between June 1991 and December 1996. The eye and tumor parameters were measured using ultrasonography and angiography. Since 1991, CT scans were performed in most patients to help determine the axial length and the shape of the ocular globe. Tantalum clips were inserted around the tumor by the referring ophthalmologist. There were 349 posterior pole tumors (64.9%), 130 equatorial tumors (24.1%), and 59 ciliary body tumors (11%). Twohundred four patients (37.9%) had T1 or T2 tumors, and 334 patients (62.1%) had T3 or T4 tumors. The median tumor diameter was 14.6 mm, and the median tumor height was 5.1 mm. All patients received 52 Gy (57.20 Gy Go-equivalent dose) on 1 consecutive days. The data were analyzed by December 1997. Results: The CSS was 77.4% at 78 months, the overall survival was 73.8% and the local control was 89.0%. The CSS was not influenced by the patient age or the site of the tumor. It was 81.5% for T1 and T2 tumors, versus 75% for T3 and T4 tumors (P = 0.035). It was found that the tumor diameter, rather than the height, was the most important parameter affecting outcome. Themetastatic rate was 8%. It depended on the T stage, tumor diameter and thickness, but not the tumor site. Thirty-eight enucleations were performed, most of them due to tumor progression and/or glaucoma. One-third of the patients in whom visual acuity was adequately scored before and after treatmenthad a stable, if not improved vision, and half the patients retained useful vision after treatment. Conclusion: The outcome of patients suffering from uveal melanoma and treated with high-energy protons compares favorably with other techniques of treatment. The tumor dimensions affected CSS and metastatic rate. Even thoughtwo-thirds of patients had posterior pole tumors, half of them retained useful vision. (C) 1999 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 19:07:48