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Titolo:
TESTING THE NEURAL SENSITIZATION AND KINDLING HYPOTHESIS FOR ILLNESS FROM LOW-LEVELS OF ENVIRONMENTAL CHEMICALS
Autore:
BELL IR; ROSSI J; GILBERT ME; KOBAL G; MORROW LA; NEWLIN DB; SORG BA; WOOD RW;
Indirizzi:
VET AFFAIRS MED CTR,DEPT PSYCHIAT,3601 S 6TH AVE,MAIL STOP 116A TUCSON AZ 85723 UNIV ARIZONA,DEPT PSYCHOL TUCSON AZ 85721 UNIV ARIZONA,DEPT PSYCHIAT TUCSON AZ 85721 UNIV ARIZONA,DEPT FAMILY & COMMUNITY MED TUCSON AZ 85721 USN,MED RES INST DETACHMENT TOXICOL,TRISERV TOXICOL CONSORTIUM WRIGHTPATTERSON AFB OH 00000 US EPA RES TRIANGLE PK NC 27711 UNIV ERLANGEN NURNBERG,DEPT PHARMACOL & TOXICOL D-8520 ERLANGEN GERMANY UNIV PITTSBURGH,DEPT PSYCHIAT PITTSBURGH PA 00000 NIDA BALTIMORE MD 21224 WASHINGTON STATE UNIV,DEPT VET & COMPARAT ANAT PHARMACOL & PHYSIOL PULLMAN WA 99164 NYU,DEPT ENVIRONM MED NEW YORK NY 10016
Titolo Testata:
Environmental health perspectives
, volume: 105, anno: 1997, supplemento:, 2
pagine: 539 - 547
SICI:
0091-6765(1997)105:<539:TTNSAK>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
TIME-DEPENDENT SENSITIZATION; ORGANIC-SOLVENT EXPOSURE; SELF-REPORTED ILLNESS; POSTTRAUMATIC-STRESS-DISORDER; BEHAVIORAL SENSITIZATION; DRUG VARIABILITY; DOPAMINE RELEASE; CHILDHOOD ABUSE; SEX-DIFFERENCES; WHITE PAPER;
Keywords:
SENSITIZATION; KINDLING; MESOLIMBIC; HUMAN; ANIMAL; TIME FACTORS; LOW-LEVEL EXPOSURES; PSYCHOPHYSIOLOGY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
102
Recensione:
Indirizzi per estratti:
Citazione:
I.R. Bell et al., "TESTING THE NEURAL SENSITIZATION AND KINDLING HYPOTHESIS FOR ILLNESS FROM LOW-LEVELS OF ENVIRONMENTAL CHEMICALS", Environmental health perspectives, 105, 1997, pp. 539-547

Abstract

Sensitization in the neuroscience and pharmacology literatures is defined as progressive increase in the size of a response over repeated presentations of a stimulus. Types of sensitization include stimulant drug-induced time-dependent sensitization (TDS), an animal model related to substance abuse, and limbic kindling, an animal model for temporal lobe epilepsy, Neural sensitization (primarily nonconvulsive or subconvulsive) to the adverse properties of substances has been hypothesized to underlie the initiation and subsequent elicitation of heightenedsensitivity to low levels of environmental chemicals. A corollary of the sensitization model is that individuals with illness from low-level chemicals are among the more sensitizable members of the population. The Working Group on Sensitization and Kindling identified two primary goals for a research approach to this problem: to perform controlledexperiments to determine whether or not sensitization to low-level chemical exposures occurs in multiple chemical sensitivity (MCS) patients; and to use animal preparations for kindling and TDS as nonhomologous models for the initiation and elicitation of MCS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/21 alle ore 01:12:25