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Titolo:
INDIVIDUAL-DIFFERENCES IN NEURAL SENSITIZATION AND THE ROLE OF CONTEXT IN ILLNESS FROM LOW-LEVEL ENVIRONMENTAL CHEMICAL EXPOSURES
Autore:
BELL IR; SCHWARTZ GE; BALDWIN CM; HARDIN EE; KLIMAS NG; KLINE JP; PATARCA R; SONG ZY;
Indirizzi:
VET ADM MED CTR,DEPT PSYCHIAT,3601 S 6TH AVE,MAIL STOP 116A TUCSON AZ85723 UNIV ARIZONA,DEPT PSYCHOL TUCSON AZ 85721 UNIV ARIZONA,DEPT PSYCHIAT TUCSON AZ 85721 UNIV ARIZONA,DEPT NEUROL TUCSON AZ 85721 UNIV ARIZONA,DIV RESP SCI TUCSON AZ 85721 UNIV MIAMI,SCH MED,DEPT MED IMMUNOL MIAMI FL 00000 VET AFFAIRS MED CTR MIAMI FL 33125
Titolo Testata:
Environmental health perspectives
, volume: 105, anno: 1997, supplemento:, 2
pagine: 457 - 466
SICI:
0091-6765(1997)105:<457:IINSAT>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
TIME-DEPENDENT SENSITIZATION; SELF-REPORTED ILLNESS; DEFICIT-HYPERACTIVITY DISORDER; BEHAVIORAL SENSITIZATION; NUCLEUS-ACCUMBENS; DRUG VARIABILITY; DOPAMINE RELEASE; OLFACTORY-BULB; MOTOR-ACTIVITY; YOUNG-ADULTS;
Keywords:
ADAPTATION; CONDITIONING; DOPAMINE; ENVIRONMENTAL CHEMICALS; KINDLING; LIMBIC; MULTIPLE CHEMICAL SENSITIVITY; SENSITIZATION; TOLERANCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
105
Recensione:
Indirizzi per estratti:
Citazione:
I.R. Bell et al., "INDIVIDUAL-DIFFERENCES IN NEURAL SENSITIZATION AND THE ROLE OF CONTEXT IN ILLNESS FROM LOW-LEVEL ENVIRONMENTAL CHEMICAL EXPOSURES", Environmental health perspectives, 105, 1997, pp. 457-466

Abstract

This paper summarizes the clinical phenomenology of multiple chemicalsensitivity (MCS), outlines the concepts and evidence for the olfactory-limbic, neural sensitization model for MCS, and discusses experimental design implications of the model for exposure-related research. Neural sensitization is the progressive amplification of responsivity bythe passage of time between repeated, intermittent exposures. Initiation of sensitization may require single toxic or multiple subtoxic exposures, but subsequent elicitation of sensitized responses can involvelon or nontoxic levels. Thus, neural sensitization could account for the ability of low levels of environmental chemicals to elicit clinically severe, adverse reactions in MCS. Different forms of sensitizationinclude limbic kindling of seizures (compare temporal lobe epilepsy and simple partial seizures) and time-dependent sensitization of behavioral, neurochemical, immunological, and endocrinological variables. Sensitized dysfunction of the limbic and mesolimbic systems could account in part for many of the cognitive, affective, and somatic symptoms in MCS. Derealization (an alteration in perception making familiar objects or people seem unfamiliar or unreal) is a common MCS symptom and has been linked with limbic dysfunction in clinical neuroscience research. Sensitization is distinct from, but interactive with, other neurobiological learning and memory processes such as conditioning and habituation (compare adaptation or tolerance). in previous studies, hypotheses for MCS involving sensitization, conditioning, and habituation (adaptation) have often been considered in isolation from one another. Todesign more appropriate chemical exposure studies, it may be important to integrate the various theoretical models and empirical approachesto MCS with the larger scientific literature on individual differences in these potentially interactive phenomena.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/21 alle ore 01:55:13