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Titolo:
A Danish national cohort of 730 infants born after intracytoplasmic sperm injection (ICSI) 1994-1997
Autore:
Loft, A; Petersen, K; Erb, K; Mikkelsen, AL; Grinsted, J; Hald, F; Hindkjaer, J; Nielsen, KM; Lundstrom, P; Gabrielsen, A; Lenz, S; Hornnes, P; Ziebe, S; Ejdrup, HB; Lindhard, A; Zhou, Y; Andersen, AN;
Indirizzi:
Univ Copenhagen, Rigshosp, Fertil Clin, DK-2100 Copenhagen O, Denmark UnivCopenhagen Copenhagen Denmark O Clin, DK-2100 Copenhagen O, Denmark Fertil Clin, DK-8270 Hojsberg, Denmark Fertil Clin Hojsberg Denmark DK-8270 til Clin, DK-8270 Hojsberg, Denmark Fertil Clin, DK-2000 Frederiksberg, Denmark Fertil Clin Frederiksberg Denmark DK-2000 DK-2000 Frederiksberg, Denmark Odense Univ Hosp, Fertil Clin, DK-5000 Odense, Denmark Odense Univ Hosp Odense Denmark DK-5000 il Clin, DK-5000 Odense, Denmark Fertil Clin, DK-5000 Odense, Denmark Fertil Clin Odense Denmark DK-5000Fertil Clin, DK-5000 Odense, Denmark Copenhagen Univ Hosp, Fertil Clin, DK-2730 Herlev, Denmark Copenhagen UnivHosp Herlev Denmark DK-2730 lin, DK-2730 Herlev, Denmark Fertil Clin Trianglen, DK-2100 Copenhagen, Denmark Fertil Clin Trianglen Copenhagen Denmark DK-2100 100 Copenhagen, Denmark Braedstrup Hosp, Fertil Clin, DK-8740 Braedstrup, Denmark Braedstrup HospBraedstrup Denmark DK-8740 , DK-8740 Braedstrup, Denmark Aarhus Univ Hosp, Fertil Clin, DK-8000 Aarhus C, Denmark Aarhus Univ HospAarhus Denmark C Fertil Clin, DK-8000 Aarhus C, Denmark Danish Fertil Clin, DK-2000 Frederiksberg, Denmark Danish Fertil Clin Frederiksberg Denmark DK-2000 Frederiksberg, Denmark Fertil Clin IVF, DK-2750 Ballerup, Denmark Fertil Clin IVF Ballerup Denmark DK-2750 IVF, DK-2750 Ballerup, Denmark Private Hosp Hamlet, Fertil Clin, DK-2000 Frederiksberg, Denmark Private Hosp Hamlet Frederiksberg Denmark DK-2000 Frederiksberg, Denmark Fertil Clin, DK-1100 Copenhagen K, Denmark Fertil Clin Copenhagen Denmark K til Clin, DK-1100 Copenhagen K, Denmark
Titolo Testata:
HUMAN REPRODUCTION
fascicolo: 8, volume: 14, anno: 1999,
pagine: 2143 - 2148
SICI:
0268-1161(199908)14:8<2143:ADNCO7>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-VITRO FERTILIZATION; CHILDREN BORN; FOLLOW-UP; TESTICULAR SPERMATOZOA; PREGNANCIES; REPLACEMENT; DEFECTS;
Keywords:
intracytoplasmic sperm injection; malformation; obstetric outcome; pregnancy outcome; prenatal karyotypes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Loft, A Univ Copenhagen Hosp, Rigshosp, Fertil Clin, Blegdamsvej 9, DK-2100 Copenhagen O, Denmark Univ Copenhagen Hosp Blegdamsvej 9 Copenhagen Denmark O , Denmark
Citazione:
A. Loft et al., "A Danish national cohort of 730 infants born after intracytoplasmic sperm injection (ICSI) 1994-1997", HUM REPR, 14(8), 1999, pp. 2143-2148

Abstract

This national cohort study included all clinical pregnancies obtained after intracytoplasmic sperm injection (ICSI) registered in Denmark between January 1994 and July 1997 at five public and eight private fertility clinics. Laboratory and clinical data were obtained from the fertility clinics. Thecouples answered a questionnaire regarding the pregnancy and the health ofthe child (response rate 94%), Data validation was carried out through discharge charts. The mean age of the women was 32.1 years. In 84.2% of couples, male factor was the main reason for performing ICSI, and in 4.8% epididymal spermatozoa were used. The mean number of embryos replaced was 2.3 (range 1-3) and in 95% of cases fresh embryos were transferred. Only 183 women (28.5%) underwent prenatal diagnosis, resulting in 209 karyotypes with seven (3.3%) chromosome aberrations. Six major chromosomal abnormalities (2.9%)and one inherited structural chromosome aberration (0.5%) were found, but no sex chromosome aberrations. The frequency of multiple birth, Caesarean section rate, gestational age, preterm birth, and birth weight were comparable with previous studies. The perinatal mortality rate was 13.7 per 1000 children born with a gestational age of 24 weeks or more, In 2.2% (n = 16) ofthe liveborn infants, and in 2.7% (n = 20) of all infants, major birth defects were reported by the parents, Minor birth defects were found in nine liveborn infants (1.2%). In conclusion, the results of this study on outcomeof ICSI pregnancies are in line with earlier reports, except that no sex chromosome abnormalities were found.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 14:45:17