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Titolo:
A distinctive composite lymphoma consisting of clonally related mantle cell lymphoma and follicle center cell lymphoma
Autore:
Tsang, P; Pan, LX; Cesarman, E; Tepler, J; Knowles, DM;
Indirizzi:
Cornell Univ, Weill Coll Med, Dept Pathol, New York, NY 10021 USA Cornell Univ New York NY USA 10021 d, Dept Pathol, New York, NY 10021 USA Cornell Univ, Weill Coll Med, Dept Med, New York, NY 10021 USA Cornell Univ New York NY USA 10021 Med, Dept Med, New York, NY 10021 USA
Titolo Testata:
HUMAN PATHOLOGY
fascicolo: 8, volume: 30, anno: 1999,
pagine: 988 - 992
SICI:
0046-8177(199908)30:8<988:ADCLCO>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
BREAKPOINT-CLUSTER REGION; B-CELL; HODGKINS-DISEASE; NEOPLASMS; REARRANGEMENTS; PROGRESSION; PROPOSAL;
Keywords:
composite lymphoma; mantle cell lymphoma; follicle center cell lymphoma; clonality;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Knowles, DM Cornell Univ, Weill Coll Med, Dept Pathol, 525 E 68th St, New York, NY 10021 USA Cornell Univ 525 E 68th St New York NY USA 10021 NY 10021 USA
Citazione:
P. Tsang et al., "A distinctive composite lymphoma consisting of clonally related mantle cell lymphoma and follicle center cell lymphoma", HUMAN PATH, 30(8), 1999, pp. 988-992

Abstract

Although follicle center cell lymphoma and mantle cell lymphoma are both Bcell non-Hodgkin's lymphomas (NHL), they are regarded as separate entitieswith distinct clinical, morphological, immunophenotypic and molecular characteristics. To our knowledge, the coexistence of these 2 lymphomas in the same patient has never been reported. We describe a 70-year-old woman with a long-standing history of follicle center cell lymphoma, cytological gradeI, who subsequently developed a composite lymphoma consisting of well-demarcated foci of persistent follicle center cell lymphoma surrounded by mantle cell lymphoma. This morphological interpretation was supported by the presence of both bcl-1 and bcl-2 gene rearrangements, which are molecular genetic hallmarks of mantle cell lymphoma and follicle center cell lymphoma, respectively. Polymerase chain reaction (PCR) analysis for rearranged immunoglobulin heavy chain (IgH) genes showed a dominant band identical in size inmicrodissected tumor cells of the follicle center cell and mantle cell lymphomas. Cloning and sequence analysis of the PCR products revealed a commonclone-specific IgH gene rearrangement in these 2 lymphomas. These findingssuggest that this composite lymphoma represents the unusual evolution of amalignant B-cell clone that resulted in the development of 2 morphologically distinct but clonally related B-cell NHLs. These findings also show the importance of integrating morphological, immunophenotypic, and molecular data to enhance our understanding of the complex pathogenic interrelationships in lymphomagenesis. (C) 1999 by W.B. Saunders Company.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 09:59:06