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Titolo:
Adapt globally, act locally: The effect of selective sweeps on bacterial sequence diversity
Autore:
Majewski, J; Cohan, FM;
Indirizzi:
Wesleyan Univ, Dept Biol, Middletown, CT 06459 USA Wesleyan Univ Middletown CT USA 06459 Dept Biol, Middletown, CT 06459 USA
Titolo Testata:
GENETICS
fascicolo: 4, volume: 152, anno: 1999,
pagine: 1459 - 1474
SICI:
0016-6731(199908)152:4<1459:AGALTE>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENETIC EXCHANGE; ESCHERICHIA-COLI; EVOLUTIONARY DIVERGENCE; PERIODIC SELECTION; COALESCENT PROCESS; RECOMBINATION; PROKARYOTES; TRANSFORMATION; POPULATIONS; MODELS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Cohan, FM Wesleyan Univ, Dept Biol, Middletown, CT 06459 USA Wesleyan Univ Middletown CT USA 06459 Middletown, CT 06459 USA
Citazione:
J. Majewski e F.M. Cohan, "Adapt globally, act locally: The effect of selective sweeps on bacterial sequence diversity", GENETICS, 152(4), 1999, pp. 1459-1474

Abstract

Previous studies have shown that genetic exchange in bacteria is too rare to prevent neutral sequence divergence between ecological populations. Thatis, despite genetic exchange, each population should diverge into its own DNA sequence-similarity cluster. In those studies, each selective sweep waslimited to acting within a single ecological population. Here we postulatethe existence of globally adaptive mutations, which may confer a selectiveadvantage to all ecological populations constituting a metapopulation. Such adaptations cause global selective sweeps, which purge the divergence both within and between populations. We found that the effect of recurrent global selective sweeps on neutral sequence divergence is highly dependent on the mechanism of genetic exchange. Global selective sweeps can prevent populations from reaching high levels of neutral sequence divergence, but they cannot cause two populations to become identical in neutral sequence characters. The model supports the earlier conclusion that each ecological population of bacteria should form its own distinct DNA sequence-similarity cluster.

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Documento generato il 31/03/20 alle ore 09:40:16