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Titolo:
Immune response to rotavirus VP4 expressed in an attenuated strain of Shigella flexneri
Autore:
Loy, AL; Allison, G; Arias, CF; Verma, NK;
Indirizzi:
Australian Natl Univ, Fac Sci, Div Biochem & Mol Biol, Canberra, ACT 0200,Australia Australian Natl Univ Canberra ACT Australia 0200 erra, ACT 0200,Australia Univ Nacl Autonoma Mexico, Inst Biotecnol, Cuernavaca 62250, Morelos, Mexico Univ Nacl Autonoma Mexico Cuernavaca Morelos Mexico 62250 Morelos, Mexico
Titolo Testata:
FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY
fascicolo: 3, volume: 25, anno: 1999,
pagine: 283 - 288
SICI:
0928-8244(19990815)25:3<283:IRTRVE>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
ESCHERICHIA-COLI; INFECTIVITY; PROTECTION; EPITOPES; PATHWAY; VACCINE; SFL124; DOMAIN;
Keywords:
fusion protein; immunogenicity; rotavirus; Shigella flexneri; viral protein 4;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Verma, NK Australian Natl Univ, Fac Sci, Div Biochem & Mol Biol, Canberra,ACT 0200,Australia Australian Natl Univ Canberra ACT Australia 0200 0200,Australia
Citazione:
A.L. Loy et al., "Immune response to rotavirus VP4 expressed in an attenuated strain of Shigella flexneri", FEMS IM MED, 25(3), 1999, pp. 283-288

Abstract

An attenuated strain of Shigella flexneri was utilised to express viral protein (VP) 4 of rotavirus and the immunogenicity of the recombinant constructs was studied in BALB/c mice. VP4 was expressed as a fusion with maltose binding protein (MBP) in both the cytoplasm and periplasm, with a much higher level of expression occurring in the former. While all constructs induced a Shigella-specific response in mice, only the construct expressing MBP-VP4 in the cytoplasm of Shigella stimulated an immune response specific to rotavirus. This study demonstrates that Shigella can be used to deliver rotavirus antigens and induces an immune response directed towards both rotavirus and Shigella. (C) 1999 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 11:09:33