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Titolo:
Lack of heat shock response triggers programmed cell death in a rat histiocytic cell line
Autore:
Sreedhar, AS; Pardhasaradhi, BVV; Begum, Z; Khar, A; Srinivas, UK;
Indirizzi:
Ctr Cellular & Mol Biol, Hyderabad 500007, Andhra Pradesh, India Ctr Cellular & Mol Biol Hyderabad Andhra Pradesh India 500007 desh, India
Titolo Testata:
FEBS LETTERS
fascicolo: 2, volume: 456, anno: 1999,
pagine: 339 - 342
SICI:
0014-5793(19990806)456:2<339:LOHSRT>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
STRESS-INDUCED APOPTOSIS; MOLECULAR CHAPERONES; PROTEINS; INDUCTION; HSP70; HEAT-SHOCK-PROTEIN-70; THERMOTOLERANCE; EXPRESSION; PROTECTS; DIFFERENTIATION;
Keywords:
heat shock response; heat shock protein; apoptosis; BC-8 cell/rat histiocytoma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Srinivas, UK Ctr Cellular & Mol Biol, Uppal Rd, Hyderabad 500007, Andhra Pradesh, India Ctr Cellular & Mol Biol Uppal Rd Hyderabad Andhra Pradesh India 500007
Citazione:
A.S. Sreedhar et al., "Lack of heat shock response triggers programmed cell death in a rat histiocytic cell line", FEBS LETTER, 456(2), 1999, pp. 339-342

Abstract

Stress response is a universal phenomenon, However, a rat histiocytic cellline, BC-8, showed no heat shock response and failed to synthesize heat shock protein 70 (hsp70) upon heat shock at 42 degrees C for 30 min. BC-8 is a clone of AK-5, a rat macrophage tumor line that is adapted to grow in culture and has the same chromosome number and tumorigenic potential as AK-5, An increase in either the incubation temperature or time or both to BC-8 cells leads to loss of cell viability. In addition, heat shock conditions activated apoptotic cell death in these cells as observed by cell fragmentation, formation of nuclear comets, apoptotic bodies, DNA fragmentation and activation of ICE-like cysteine proteases, Results presented here demonstrate that BC-8 cells cannot mount a typical heat shock response unlike all othereukaryotic cells and that in the absence of induction of hsps upon stress,these cells undergo apoptosis at 42 degrees C. (C) 1999 Federation of European Biochemical Societies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 03:48:44