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Titolo:
Curcumin mediated apoptosis in AK-5 tumor cells involves the production ofreactive oxygen intermediates
Autore:
Bhaumik, S; Anjum, R; Rangaraj, N; Pardhasaradhi, BVV; Khar, A;
Indirizzi:
Ctr Cellular & Mol Biol, Hyderabad 500007, Andhra Pradesh, India Ctr Cellular & Mol Biol Hyderabad Andhra Pradesh India 500007 desh, India
Titolo Testata:
FEBS LETTERS
fascicolo: 2, volume: 456, anno: 1999,
pagine: 311 - 314
SICI:
0014-5793(19990806)456:2<311:CMAIAT>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYTOCHROME-C; PLASMA-MEMBRANE; SUPEROXIDE ANION; MITOCHONDRIAL; PHOSPHATIDYLSERINE; RELEASE; BCL-2; OVEREXPRESSION; PERMEABILITY; ANTIOXIDANT;
Keywords:
reactive oxygen metabolite; AK-5 cell; curcumin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Khar, A Ctr Cellular & Mol Biol, Uppal Rd, Hyderabad 500007, Andhra Pradesh, India Ctr Cellular & Mol Biol Uppal Rd Hyderabad Andhra Pradesh India 500007
Citazione:
S. Bhaumik et al., "Curcumin mediated apoptosis in AK-5 tumor cells involves the production ofreactive oxygen intermediates", FEBS LETTER, 456(2), 1999, pp. 311-314

Abstract

Curcumin, the active ingredient of the rhizome of Curcuma longa has anti-inflammatory, antioxidant and antiproliferative activities. Although its precise mode of action remains elusive, studies have shown that chemopreventive action of curcumin might be due to its ability to induce apoptosis in cancer cells, Curcumin was shown to be responsible for the inhibition of AK-5 tumor (a rat histiocytoma) growth by inducing apoptosis in AK-5 tumor cellsvia caspase activation, This study was designed to investigate the mechanism leading to the induction of apoptosis in AK-5 tumor cells, Curcumin treatment resulted in the hyperproduction of reactive oxygen species (ROS), loss of mitochondrial membrane potential (Delta Psi(m)) and cytochrome c release to the cytosol, with the concomitant exposure of phosphatidylserine (PS)residues on the cell surface. This study suggests redox signalling and caspase activation as the mechanisms responsible for the induction of curcuminmediated apoptosis in AK-5 tumor cells, (C) 1999 Federation of European Biochemical Societies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 13:49:28