Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Regulation of dopamine-induced natriuresis by the dopamine-metabolizing enzyme catechol-O-methyltransferase
Autore:
Odlind, C; Goransson, V; Reenila, I; Hansell, P;
Indirizzi:
Uppsala Univ, Dept Physiol, Biomed Ctr, SE-75123 Uppsala, Sweden Uppsala Univ Uppsala Sweden SE-75123 iomed Ctr, SE-75123 Uppsala, Sweden Univ Helsinki, Dept Pharmacol & Toxicol, Inst Biomed, FIN-00170 Helsinki, Finland Univ Helsinki Helsinki Finland FIN-00170 ed, FIN-00170 Helsinki, Finland
Titolo Testata:
EXPERIMENTAL NEPHROLOGY
fascicolo: 4, volume: 7, anno: 1999,
pagine: 314 - 322
SICI:
1018-7782(199907/08)7:4<314:RODNBT>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROXIMAL CONVOLUTED TUBULE; K+-ATPASE ACTIVITY; PERFORMANCE LIQUID-CHROMATOGRAPHY; URINARY DOPAMINE; ELECTROCHEMICAL DETECTION; ESSENTIAL-HYPERTENSION; ADENYLATE-CYCLASE; RENAL DOPAMINE; HIGH-SALT; RAT;
Keywords:
dopamine; kidney; sodium; COMT; entacapone; dopamine receptors; DOPAC; L-dopa;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Hansell, P Uppsala Univ, Dept Physiol, Biomed Ctr, BMC,POB 572, SE-75123 Uppsala, Sweden Uppsala Univ BMC,POB 572 Uppsala Sweden SE-75123 psala, Sweden
Citazione:
C. Odlind et al., "Regulation of dopamine-induced natriuresis by the dopamine-metabolizing enzyme catechol-O-methyltransferase", EXP NEPHROL, 7(4), 1999, pp. 314-322

Abstract

Dopamine (DA) is an intrarenal natriuretic hormone involved in sodium homeostasis. A study was performed to elucidate two possible regulatory pathways of DA-induced natriuresis, i.e., metabolism and precursor delivery. This was done by use of an intraperitoneal injection of a catechol-O-methyltransferase (COMT) inhibitor, entacapone, or intravenous infusion of the DA precursor, L-dopa. Entacapone (30 mg/kg i.p.) induced a more than fivefold increase in renal sodium excrection which occurred without changes in renal haemodynamics. The natriuretic response was highly dependent on DA D-1-like receptor activation, since the selective D-1-like receptor antagonist SCH23390 attenuated the natriuretic response by 61%, while the selective D-2-like receptor antagonist sulpiride was ineffective. The urinary excretion of DA did not increase. Infusion of L-dopa (60 mu g/h/kg) only induced a twofold increase in sodium excretion, but the urinary excretion of DA increased more than 17-fold. The L-dopa-induced natriuretic response occurred without increments in glomerular filtration rate and could be blocked with the D-1-like receptor antagonist SCH23390. It is concluded that the DA-metabolizing enzyme COMT is involved in the regulation of the natriuretic effect of intrarenal DA, It may be speculated that intrarenal DA activity is not primarilydetermined on the basis of delivered precursor, but on that of the level of DA metabolism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 10:09:41