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Titolo:
Solid state studies of drug-cyclodextrin inclusion complexes in PEG 6000 prepared by a new method
Autore:
Wulff, M; Alden, M;
Indirizzi:
Univ Uppsala, Ctr Biomed, Dept Pharmaceut Chem Phys & Inorgan Chem, S-75123 Uppsala, Sweden Univ Uppsala Uppsala Sweden S-75123 norgan Chem, S-75123 Uppsala, Sweden
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
fascicolo: 4, volume: 8, anno: 1999,
pagine: 269 - 281
SICI:
0928-0987(199908)8:4<269:SSSODI>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
BETA-CYCLODEXTRIN; GAMMA-CYCLODEXTRIN; ALPHA-CYCLODEXTRIN; POLYETHYLENE-GLYCOL; PHASE-EQUILIBRIA; INDOMETHACIN; DISPERSIONS; DERIVATIVES; DISSOLUTION; STABILITY;
Keywords:
indomethacin; griseofulvin; cyclodextrins; X-ray powder diffraction; MTDSC; ODSC; dissolution; crystallinity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Alden, M Univ Uppsala, Ctr Biomed, Dept Pharmaceut Chem Phys & Inorgan Chem, Box 574, S-75123 Uppsala, Sweden Univ Uppsala Box 574 Uppsala Sweden S-75123 5123 Uppsala, Sweden
Citazione:
M. Wulff e M. Alden, "Solid state studies of drug-cyclodextrin inclusion complexes in PEG 6000 prepared by a new method", EUR J PH SC, 8(4), 1999, pp. 269-281

Abstract

The melting method was investigated as a possible method for producing drug-cyclodextrin (CD) inclusion compounds in a carrier. Various solid dispersions of alpha-, beta- and gamma-CD in polyethylene glycol (PEG) 6000 with and without the addition of 5% w/w indomethacin or griseofulvin were prepared using the original components. Characterisations of the samples included X-ray powder diffraction, modulated-temperature differential scanning calorimetry and dissolution tests by the paddle method according to USP XXI standard. Evidence of a complex between indomethacin and beta-CD in PEG 6000 was found. An indomethacin-gamma-CD complex formed a well defined phase in the PEG carrier, with tetragonal structure and unit cell parameters a = 23.885(35) Angstrom and c = 23.181(64) Angstrom. No complexation of indomethacinwith alpha-CD, or with griseofulvin and beta-CD could be detected. It is suggested that competition between PEG and the drug for the binding to different CDs along with varying patterns of water loss from the CDs influence the inclusion reaction. The formation of complexes was accompanied by a decrease in the relative crystallinity of the dispersions. Dissolution tests showed that the CDs have a delaying effect on the release of indomethacin from PEG 6000 in the order alpha-CD<gamma-CD less than or equal to beta-CD. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 03:24:40