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Titolo:
Placental transfer of the thromboxane synthetase inhibitor ridogrel in thelate-pregnant ewe
Autore:
Schneider, TJ; Struijk, PC; Wallenburg, HCS;
Indirizzi:
Erasmus Univ, Sch Med & Hlth Sci EE2283, Dept Obstet & Gynecol, NL-3000 DRRotterdam, Netherlands Erasmus Univ Rotterdam Netherlands NL-3000 DR 0 DRRotterdam, Netherlands
Titolo Testata:
EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY
fascicolo: 1, volume: 86, anno: 1999,
pagine: 83 - 87
SICI:
0301-2115(199909)86:1<83:PTOTTS>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED HYPERTENSION; ENDOPEROXIDE SHUNT; ONE MOLECULE; PROSTACYCLIN; R-68070; INVIVO; 3RD;
Keywords:
ridogrel; thromboxane synthetase inhibition; pregnant ewe;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Wallenburg, HCS Erasmus Univ, Sch Med & Hlth Sci EE2283, Dept Obstet & Gynecol, POB 1738, NL-3000 DR Rotterdam, Netherlands Erasmus Univ POB 1738 Rotterdam Netherlands NL-3000 DR ds
Citazione:
T.J. Schneider et al., "Placental transfer of the thromboxane synthetase inhibitor ridogrel in thelate-pregnant ewe", EUR J OB GY, 86(1), 1999, pp. 83-87

Abstract

Objectives: To assess the occurrence of placental transfer of the thromboxane synthetase inhibitor ridogrel in the pregnant ewe and to determine its effect on prostanoid levels in the ewe and fetal lamb, on uterine contractility and on maternal and fetal hemodynamics. Study design: Five chronicallyinstrumented pregnant ewes at 122 days of gestation received intravenous infusions of 5 mg/kg/3 h ridogrel and solvent. Maternal and fetal arterial samples were obtained at predetermined intervals to determine concentrationsof ridogrel and prostaglandin metabolites TXB2, 6-keto-PGF(1)alpha, PGF(2)alpha, and PGE(2). Maternal and fetal responses of blood flow and pressureswere determined. Results: Fetal ridogrel levels were 25% of maternal concentrations. Ridogrel showed rapid and marked thromboxane synthetase inhibition and augmentation of levels of prostaglandin metabolites. There was no evidence of change in amniotic pressure, uterine blood flow, maternal and fetal blood pressure and heart rate. Conclusion: Ridogrel is a potent thromboxane synthetase inhibitor which passes the sheep placenta, does not influence maternal and fetal hemodynamics and uterine contractility, and shows similar antiplatelet activity in the ewe and the fetal lamb. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 22:48:43