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Titolo:
Heart failure-related myopathy - Clinical and pathophysiological insights
Autore:
Opasich, C; Ambrosino, N; Felicetti, G; Aquilani, R; Pasini, E; Bergitto, D; Mazza, A; Cobelli, F; Tavazzi, L;
Indirizzi:
IRCCS, Fondaz S Maugeri, Div Cardiol, Inst Care & Res, I-27100 Pavia, Italy IRCCS Pavia Italy I-27100 Cardiol, Inst Care & Res, I-27100 Pavia, Italy S Maugeri Fdn, Inst Care & Res, Div Pulm, Gussago, Italy S Maugeri Fdn Gussago Italy , Inst Care & Res, Div Pulm, Gussago, Italy S Maugeri Fdn, Inst Care & Res, Rehabil Div, Pavia, Italy S Maugeri Fdn Pavia Italy n, Inst Care & Res, Rehabil Div, Pavia, Italy S Maugeri Fdn, Inst Care & Res, Serv Nutr Pathophysiol, Pavia, Italy S Maugeri Fdn Pavia Italy e & Res, Serv Nutr Pathophysiol, Pavia, Italy Policlin San Matteo, Dept Cardiol, Inst Care & Res, I-27100 Pavia, Italy Policlin San Matteo Pavia Italy I-27100 Care & Res, I-27100 Pavia, Italy
Titolo Testata:
EUROPEAN HEART JOURNAL
fascicolo: 16, volume: 20, anno: 1999,
pagine: 1191 - 1200
SICI:
0195-668X(199908)20:16<1191:HFM-CA>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY MUSCLE STRENGTH; LEFT-VENTRICULAR DYSFUNCTION; SKELETAL-MUSCLE; EXERCISE CAPACITY; OXYGEN-CONSUMPTION; VENTILATORY DRIVE; CARDIAC-FAILURE; GAS-EXCHANGE; ABNORMALITIES; PERFORMANCE;
Keywords:
heart failure; skeletal muscles; respiratory muscles; exercise tolerance;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Opasich, C IRCCS, Fondaz S Maugeri, Div Cardiol, Inst Care & Res, V Ferrata 4, I-27100 Pavia, Italy IRCCS V Ferrata 4 Pavia Italy I-27100 4, I-27100 Pavia, Italy
Citazione:
C. Opasich et al., "Heart failure-related myopathy - Clinical and pathophysiological insights", EUR HEART J, 20(16), 1999, pp. 1191-1200

Abstract

Aims To evaluate the relationship of skeletal and respiratory muscular dysfunction with the degree of clinical severity, cardiac impairment and exercise intolerance in patients with chronic heart failure. Methods and Results Ninety-one patients (age 52.7 +/- 8 years) on standardtherapy and in a stable clinical condition with normal nutritional status underwent evaluation of (1) clinical severity and metabolic status (NYHA class, weight, albuminaemia, natraemia, cortisol, insulin, neurohormones), (2) cardiac function (Echo, right heart catheterization), (3) exercise tolerance (peak VO2,), (4) dynamic isokinetic forces of the quadriceps and hamstring (Cybex method), and respiratory muscle strength (maximal inspiratory and expiratory pressures). Fifty patients had a peak VO2 <14 ml.kg(-1).min(-1) (10.6 +/- 2) and 41 had values greater than or equal to 14 (18.3 +/- 4). In the former group, leg and respiratory strength were significantly lower (extensors: 80 +/- 24 vs 100.9 +/- 22 Nm; flexors: 48.5 +/- 24 vs 75.3 +/- 22, both P < 0.001; maximal expiratory pressure: 85.5 +/- 30 vs 104.8 +/- 31, P < 0.01). Muscular strength was not related to indices of clinical severity, metabolic status, neurohormones or to the degree of systolic/diastolic cardiac function, but it was related to weight and age. Multivariate analysis of the peak VO2 with clinical, haemodynamic and peripheral indicators showed weight (beta=0.32, P=0.007), muscular strength (beta=0.32, P=0.01) and NYHA class (beta=0.31, P=0.001) as the only independent predictors. The joint adjusted R-2 value was 0.48 (P<0.001). Conclusion Muscular dysfunction is part of the syndrome of heart failure. Together with symptom perception, it predicts nearly half of the variation in exercise tolerance.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 23:05:17