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Titolo:
Cisternal S100 protein and neuron-specific enolase are elevated and site-specific markers in intractable temporal lobe epilepsy
Autore:
Steinhoff, BJ; Tumani, H; Otto, M; Mursch, K; Wiltfang, J; Herrendorf, G; Bittermann, HJ; Felgenhauer, K; Paulus, W; Markakis, E;
Indirizzi:
Univ Gottingen, Dept Clin Neurophysiol, Zentrum Neurol Med, D-37075 Gottingen, Germany Univ Gottingen Gottingen Germany D-37075 Med, D-37075 Gottingen, Germany Univ Gottingen, Dept Neurol, D-3400 Gottingen, Germany Univ Gottingen Gottingen Germany D-3400 eurol, D-3400 Gottingen, Germany Univ Gottingen, Dept Neurosurg, D-3400 Gottingen, Germany Univ Gottingen Gottingen Germany D-3400 osurg, D-3400 Gottingen, Germany Univ Gottingen, Dept Psychiat, D-3400 Gottingen, Germany Univ Gottingen Gottingen Germany D-3400 chiat, D-3400 Gottingen, Germany
Titolo Testata:
EPILEPSY RESEARCH
fascicolo: 1, volume: 36, anno: 1999,
pagine: 75 - 82
SICI:
0920-1211(199908)36:1<75:CSPANE>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
CREUTZFELDT-JAKOB-DISEASE; CEREBROSPINAL-FLUID; NEUROLOGICAL-DISORDERS; S-100 PROTEIN; NERVOUS-SYSTEM; SERUM; CELLS;
Keywords:
cerebrospinal fluid; biochemical markers; temporal lobe epilepsy; foramen ovale electrodes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Steinhoff, BJ Univ Gottingen, Dept Clin Neurophysiol, Zentrum Neurol Med, Robert Koch Str 40, D-37075 Gottingen, Germany Univ Gottingen Robert Koch Str 40 Gottingen Germany D-37075
Citazione:
B.J. Steinhoff et al., "Cisternal S100 protein and neuron-specific enolase are elevated and site-specific markers in intractable temporal lobe epilepsy", EPILEPSY R, 36(1), 1999, pp. 75-82

Abstract

In the brain, S100 protein and neuron-specific enolase (NSE) are mainly found in glial cells and neurons, respectively. We investigated concentrations of S100 protein and NSE in cisternal cerebrospinal fluid obtained during implantation of foramen ovale electrodes in eight patients with temporal lobe epilepsy (TLE). In addition, the meningeal markers cystatin-C and beta-trace as well as total protein were measured. Patients with trigeminal neuralgia (TN) undergoing glycerol rhizotomy served as controls. S100 protein and NSE levels ipsilateral to the site of seizure onset were significantly higher than in TN. Contralateral TLE values were also markedly but not significantly elevated. The meningeal markers cystatin-C and beta-trace protein as well as total protein did not differ in TLE and TN. We conclude that interictal temporal lobe dysfunction corresponds with neuronal and glial markerelevations in the extracellular space and that site-specific elevations may predict the site of seizure origin biochemically. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 01:52:11