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Titolo:
Colorectal cancer in hereditary breast cancer kindreds
Autore:
Lin, KM; Ternent, CA; Adams, DR; Thorson, AG; Blatchford, GJ; Christensen, MA; Watson, P; Lynch, HT;
Indirizzi:
Creighton Univ, Sch Med, Dept Surg, Sect Colon & Rectal Surg, Omaha, NE 68131 USA Creighton Univ Omaha NE USA 68131 olon & Rectal Surg, Omaha, NE 68131 USA Creighton Univ, Sch Med, Dept Prevent Med, Omaha, NE 68131 USA Creighton Univ Omaha NE USA 68131 , Dept Prevent Med, Omaha, NE 68131 USA Creighton Univ, Sch Med, Hereditary Canc Inst, Omaha, NE 68131 USA Creighton Univ Omaha NE USA 68131 reditary Canc Inst, Omaha, NE 68131 USA
Titolo Testata:
DISEASES OF THE COLON & RECTUM
fascicolo: 8, volume: 42, anno: 1999,
pagine: 1041 - 1045
SICI:
0012-3706(199908)42:8<1041:CCIHBC>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
OVARIAN-CANCER; BRCA1; GENE; MUTATIONS; POPULATION; FAMILIES; REGION; COLON; WOMEN; TUMOR;
Keywords:
breast neoplasms, genetics; breast neoplasms, mortality; genes, BRCA1, genetics; colorectal neoplasms, genetics;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Ternent, CA Creighton Univ, Sch Med, Dept Surg, Sect Colon & Rectal Surg, 601 N 30th St,Suite 3520, Omaha, NE 68131 USA Creighton Univ 601 N 30th St,Suite 3520 Omaha NE USA 68131 USA
Citazione:
K.M. Lin et al., "Colorectal cancer in hereditary breast cancer kindreds", DIS COL REC, 42(8), 1999, pp. 1041-1045

Abstract

PURPOSE: This study compared characteristics of colorectal cancer between families with dominant breast cancer inheritance and the general population. The cumulative incidence of colorectal cancer was also studied in genetically determined breast cancer syndrome subjects with BRCA1 and BRCA2 mutations and compared with the general population. METHODS: Subjects included 42patients with colorectal cancer from 32 clinically determined hereditary breast cancer kindreds based on the autosomal dominant inheritance of breastcancers and early age of onset. The general population colorectal cancer cohort was composed of 755 patients from a tumor registry. Lifetime risk of colorectal cancer was determined in 164 BRCA1 and 88 BRCA2 gene mutation carriers and compared with the general population. Mean age of colorectal cancer onset, anatomic site distribution, histologic stage at presentation, and five year stage-stratified survival rates were compared between clinically determined hereditary breast cancer family members and the general population. RESULTS: The lifetime risk of colorectal cancer in male BRCA1 and BRCA2 mutation carriers was 5.6 percent, which was not different from 6 percent in males from the general population. Likewise, the lifetime colorectal cancer risk in female BRCA1 and BRCA2 mutation carriers was 3.2 percent, which was not different from 5.9 percent in females from the general population. Mean age of onset +/- standard error for patients with colorectal cancerwas 60 +/- 2 years for hereditary breast cancer kindreds compared with 67 /- 0.4 years for the general population (P = 0.0004). Colorectal cancer site distribution did not vary between hereditary breast cancer and the general population. Overall colorectal cancer stage distribution was significantly different, with more Stage I and fewer Stage IV cancers in subjects withhereditary breast cancer compared with the general population (P = 0.01). Overall five year stage-stratified colorectal cancer survival rate +/- standard error was 66 +/- 8 percent for hereditary breast cancer kindreds and 46 +/- 2 percent for the general population (P = 0.023). CONCLUSION: Lifetime cumulative colorectal cancer incidence in subjects with BRCA1 and BRCA2 gene mutations was not different from the general population. However, significant differences in colorectal cancer were noted between hereditary breast cancer family members and the general population. Hereditary breast cancer-associated colorectal cancer had an earlier age of onset, lower tumor stage, and better survival tate than the general population. Except for age ofonset, colorectal cancer in hereditary breast cancer kindreds exhibited more favorable characteristics than colorectal cancer in the general population.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 23:02:57