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Titolo:
Serotonin 2A receptor mRNA levels in the neonatal dopamine-depleted rat striatum remain upregulated following suppression of serotonin hyperinnervation
Autore:
Basura, GJ; Walker, PD;
Indirizzi:
Wayne State Univ, Sch Med, Dept Anat & Cell Biol, Detroit, MI 48201 USA Wayne State Univ Detroit MI USA 48201 & Cell Biol, Detroit, MI 48201 USA Wayne State Univ, Sch Med, Cellular & Clin Neurobiol Program, Dept Psychiat & Behav Neurosci, Detroit, MI 48201 USA Wayne State Univ Detroit MI USA 48201 hav Neurosci, Detroit, MI 48201 USA
Titolo Testata:
DEVELOPMENTAL BRAIN RESEARCH
fascicolo: 1, volume: 116, anno: 1999,
pagine: 111 - 117
SICI:
0165-3806(19990805)116:1<111:S2RMLI>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADULT-RAT; GENE-EXPRESSION; MESSENGER-RNA; 6-HYDROXYDOPAMINE LESION; NIGROSTRIATAL PATHWAY; NERVOUS-SYSTEM; BRAIN-LESIONS; NEOSTRIATUM; NEURONS; TERMINALS;
Keywords:
6-hydroxydopamine; 5,7-dihydroxytryptamine; in situ hybridization; serotonin 2C receptor; basal ganglia; substantia nigra; dorsal raphe;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Walker, PD Wayne State Univ, Sch Med, Dept Anat & Cell Biol, 9352 Gordon HScott Hall,540 E Canfield Ave, Detroit, MI 48201 USA Wayne State Univ 9352Gordon H Scott Hall,540 E Canfield Ave Detroit MI USA 48201
Citazione:
G.J. Basura e P.D. Walker, "Serotonin 2A receptor mRNA levels in the neonatal dopamine-depleted rat striatum remain upregulated following suppression of serotonin hyperinnervation", DEV BRAIN R, 116(1), 1999, pp. 111-117

Abstract

Sixty days after bilateral dopamine (DA) depletion (> 98%) with 6-hydroxydopamine (6-OHDA) in neonatal rats, serotonin (5-MT) content doubled and 5-HT2A receptor mRNA expression rose 54% within the rostral striatum. To determine if striatal 5-HT2A receptor mRNA upregulation is dependent on increased 5-HT levels following DA depletion, neonatal rats received dual injections of 6-OHDA and 5,7-dihydroxytryptamine (5,7-DHT) which suppressed 5-HT content by approximately 90%. In these 6-OHDA/5,7-DHT-treated rats, striatal 5-HT2A receptor mRNA expression was still elevated (87% above vehicle controls). Comparative analysis of 5-HT2A receptor mRNA expression yielded no significant changes in any experimental group. These results demonstrate that upregulated 5-HT2A receptor biosynthesis in the DA-depleted rat is not dependent on subsequent 5-HT hyperinnervation. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 13:33:20