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Titolo:
Neuropathology of chromosome-17-linked dementia
Autore:
Sima, AAF; DAmato, C; Foster, NL;
Indirizzi:
Wayne State Univ, Dept Pathol, Detroit, MI 48201 USA Wayne State Univ Detroit MI USA 48201 Dept Pathol, Detroit, MI 48201 USA Wayne State Univ, Dept Neurol, Detroit, MI 48201 USA Wayne State Univ Detroit MI USA 48201 Dept Neurol, Detroit, MI 48201 USA Univ Michigan, Dept Pathol, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 Dept Pathol, Ann Arbor, MI 48109 USA Univ Michigan, Dept Neurol, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 Dept Neurol, Ann Arbor, MI 48109 USA
Titolo Testata:
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
, volume: 10, anno: 1999, supplemento:, 1
pagine: 61 - 63
SICI:
1420-8008(1999)10:<61:NOCD>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
AUTOSOMAL-DOMINANT PARKINSONISM; FRONTAL-LOBE DEGENERATION; NON-ALZHEIMER TYPE; FRONTOTEMPORAL DEMENTIA; PATHOLOGY; FAMILY;
Keywords:
dementia; chromosome 17; frontotemporal atrophy; neuronal inclusions; glial cytoplasmic inclusions;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Sima, AAF Wayne State Univ, Dept Pathol, 540 E Canfield Ave, Detroit, MI 48201 USA Wayne State Univ 540 E Canfield Ave Detroit MI USA 48201 201 USA
Citazione:
A.A.F. Sima et al., "Neuropathology of chromosome-17-linked dementia", DEMENT G C, 10, 1999, pp. 61-63

Abstract

We describe the characteristic neuropathologic changes in chromosome-17-linked dementia. Identified cases to date demonstrate a uniform pathology consisting of neuronal loss, gliosis and vacuolization of frontal, anterior cingulate and temporal cortex and occipital association areas, Similar changes are present in substantia nigra, ventral striatum and amygdala, Hippocampus itself is spared, whereas the afferent perforant tract is consistently affected. Characteristic neuronal inclusions consisting of lattice-like neurofilaments are present in subcortical nuclei and glial cytoplasmic tau-positive inclusions are present throughout the white matter. These pathologic changes appear to be unique for chromosome-17-linked dementia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 01:42:00