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Titolo:
Comparative cognitive neuropsychological studies of frontal lobe function:Implications for therapeutic strategies in frontal variant frontotemporal dementia
Autore:
Rahman, S; Robbins, TW; Sahakian, BJ;
Indirizzi:
Univ Cambridge, Dept Psychiat, Cambridge CB2 1TN, England Univ Cambridge Cambridge England CB2 1TN iat, Cambridge CB2 1TN, England Univ Cambridge, Dept Expt Psychol, Cambridge CB2 1TN, England Univ Cambridge Cambridge England CB2 1TN hol, Cambridge CB2 1TN, England
Titolo Testata:
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
, volume: 10, anno: 1999, supplemento:, 1
pagine: 15 - 28
SICI:
1420-8008(1999)10:<15:CCNSOF>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPATIAL WORKING-MEMORY; CEREBRAL BLOOD-FLOW; HUMAN PREFRONTAL CORTEX; ALZHEIMER-TYPE DEMENTIA; CARD SORT TEST; PARKINSONS-DISEASE; VISUOSPATIAL MEMORY; HUNTINGTONS-DISEASE; AMYGDALO-HIPPOCAMPECTOMY; SUBCORTICAL CIRCUITS;
Keywords:
comparative studies; dopamine; dorsolateral; frontotemporal dementia; idazoxan; noradrenaline; orbitofrontal; prefrontal; serotonin; therapeutic strategies;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
93
Recensione:
Indirizzi per estratti:
Indirizzo: Sahakian, BJ Univ Cambridge, Addenbrookes Hosp, Sch Clin Med, Dept Psychiat, Hills Rd, Cambridge CB2 2QQ, England Univ Cambridge Hills Rd Cambridge England CB2 2QQ Q, England
Citazione:
S. Rahman et al., "Comparative cognitive neuropsychological studies of frontal lobe function:Implications for therapeutic strategies in frontal variant frontotemporal dementia", DEMENT G C, 10, 1999, pp. 15-28

Abstract

Patients with mild frontal va ria nt frontotemporal dementia (fvTTD) who attend the clinic are usually unaware of the pervasive changes in their personality and behaviour, despite the fact it is these changes which have prompted the referral from the patient's spouse or carer. Comparative studies across various species offer unique insights into the heterogeneous structure and functions of the prefrontal cortex, and can allow a novel approach tothe precise identification of the neuropsychological deficits present in these patients. We have found that they may show marked deficits on tests sensitive to ventromedial prefrontal or orbitofrontal function, in the relative absence of impairments on tests sensitive to dorsolateral prefrontal function. We highlight important differences in the neurocognitive profile of these patients with that of patients with other neurodegenerative conditions, including basal ganglia diseases and dementia of the Alzheimer type. Thespecific nature of these neuropsychological deficits, together with converging evidence from clinical and neuropathological studies, may provide useful clues about the predominant locus of dysfunction in the early stages of fvFTD and possible underlying neurotransmitter abnormalities. This is important for the successful development of therapeutic intervention strategies for both cognitive and behavioural symptoms in fvFTD, Finally, we evaluate critically the rationales for therapeutic modulation of noradrenergic, serotonergic and dopaminergic neurotransmitter systems at various stages of disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 03:49:09