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Titolo:
Symptomatic pharmacotherapy of migraine
Autore:
Lobo, BL; Cooke, SC; Landy, SH;
Indirizzi:
Methodist Healthcare Cent, Dept Pharm, Memphis, TN 38104 USA Methodist Healthcare Cent Memphis TN USA 38104 arm, Memphis, TN 38104 USA Memphis Mental Hlth Inst, Memphis, TN USA Memphis Mental Hlth Inst Memphis TN USA ental Hlth Inst, Memphis, TN USA Wesley Headache Clin, Memphis, TN USA Wesley Headache Clin Memphis TN USA esley Headache Clin, Memphis, TN USA
Titolo Testata:
CLINICAL THERAPEUTICS
fascicolo: 7, volume: 21, anno: 1999,
pagine: 1118 - 1130
SICI:
0149-2918(199907)21:7<1118:SPOM>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIHYDROERGOTAMINE NASAL SPRAY; DOUBLE-BLIND TRIAL; SUBCUTANEOUS SUMATRIPTAN; ORAL SUMATRIPTAN; HEADACHE; EFFICACY; EMERGENCY; PROCHLORPERAZINE; METOCLOPRAMIDE; SAFETY;
Keywords:
migraine headache; ergot alkaloids; triptans; serotonin agonists;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Lobo, BL Methodist Healthcare Cent, Dept Pharm, Memphis, TN 38104 USA Methodist Healthcare Cent Memphis TN USA 38104 his, TN 38104 USA
Citazione:
B.L. Lobo et al., "Symptomatic pharmacotherapy of migraine", CLIN THER, 21(7), 1999, pp. 1118-1130

Abstract

This review summarizes data on the effectiveness of various symptomatic migraine pharmacotherapies and makes recommendations for treatment. A wide variety of agents are available for the symptomatic treatment of migraine headache, including over-the-counter analgesics, nonsteroidal anti-inflammatory drugs (NSAIDs), combination products, opiates, ergot alkaloids, corticosteroids, dopamine antagonists, and triptans, In the stepped-care approach, simple analgesics and NSAIDs are the recommended first step for the treatment of mild-to-moderate migraine headaches. Patients who do not respond to first-step treatments may be given ergots, combination products, dopamine antagonists, or triptans as the second step. Corticosteroids or opiates may beused as rescue treatment in patients who do not respond to second-step treatment. A stratified approach to care individualizes treatment based on theseverity of the headache and other patient-specific factors. In a stratified approach, dihydroergotamine or triptans may be the first-step treatment for patients who present with a history of severe migraines that have responded poorly to previous treatments. Sumatriptan was the first triptan approved for the symptomatic treatment of migraine headache; newer triptans include zolmitriptan, naratriptan, and rizatriptan. Since sumatriptan is rapidly absorbed by the subcutaneous route, its time to onset of effect is shortest. Among triptan drugs that are administered orally, the relative time to onset may be shorter with rizatriptan than sumatriptan. Naratriptan has a longer time to onset but is associated with a lower rate of migraine recurrence than other triptans.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 17:10:13