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Titolo:
Enhanced levels of soluble and membrane-bound CD40 ligand in patients withunstable angina - Possible reflection of T lymphocyte and platelet involvement in the pathogenesis of acute coronary syndromes
Autore:
Aukrust, P; Muller, F; Ueland, T; Berget, T; Aaser, E; Brunsvig, A; Solum, NO; Forfang, K; Froland, SS; Gullestad, L;
Indirizzi:
Univ Oslo, Rikshosp, Dept Med, Endocrinol Sect, N-0027 Oslo, Norway Univ Oslo Oslo Norway N-0027 t Med, Endocrinol Sect, N-0027 Oslo, Norway Univ Oslo, Rikshosp, Sect Clin Immunol & Infect Dis, N-0027 Oslo, Norway Univ Oslo Oslo Norway N-0027 n Immunol & Infect Dis, N-0027 Oslo, Norway Univ Oslo, Rikshosp, Internal Med Res Inst, N-0027 Oslo, Norway Univ OsloOslo Norway N-0027 Internal Med Res Inst, N-0027 Oslo, Norway Univ Oslo, Rikshosp, Dept Cardiol, Div Heart & Lung Dis, N-0027 Oslo, Norway Univ Oslo Oslo Norway N-0027 , Div Heart & Lung Dis, N-0027 Oslo, Norway
Titolo Testata:
CIRCULATION
fascicolo: 6, volume: 100, anno: 1999,
pagine: 614 - 620
SICI:
0009-7322(19990810)100:6<614:ELOSAM>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE CELLS; ENDOTHELIAL-CELLS; TISSUE FACTOR; ACTIVATION; EXPRESSION; MACROPHAGES; RESPONSES; PLAQUE; GP39; DISEASE;
Keywords:
angina; platelets; T cells; immunology; CD40; atherosclerosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Aukrust, P Univ Oslo, Rikshosp, Dept Med, Endocrinol Sect, N-0027 Oslo, Norway Univ Oslo Oslo Norway N-0027 crinol Sect, N-0027 Oslo, Norway
Citazione:
P. Aukrust et al., "Enhanced levels of soluble and membrane-bound CD40 ligand in patients withunstable angina - Possible reflection of T lymphocyte and platelet involvement in the pathogenesis of acute coronary syndromes", CIRCULATION, 100(6), 1999, pp. 614-620

Abstract

Background-The CD40 ligand (CD40L) on activated T cells and platelets may be activating matrix metalloproteinases, inducing procoagulant activity, and be involved in the pathogenesis of acute coronary syndromes by promoting plaque rupture in atheroma. Methods and Results-To study the role of CD40L-CD40 interaction in coronary disease, we analyzed levels of soluble (s) and membrane-bound CD40L in the peripheral blood from 29 patients with stable angina, 26 with unstable angina, and 19 controls. Our main findings follow. (1) Patients with unstableangina had significantly raised serum levels of sCD40L when compared with patients with stable angina and controls. (2) Platelets could release largeamounts of sCD40L when stimulated ex vivo with the thrombin receptor-agonist peptide SFLLRN in both patients and controls. (3) Platelets in patients with unstable angina were characterized ex vivo by decreased intracellular levels and decreased SFLLRN-stimulated release of sCD40L, which may possibly represent a higher percentage of degranulated platelets in these patients. (4) T cells in patients with unstable angina had enhanced surface expression of CD40L and increased release of sCD40L on anti-CD3/anti-CD28 stimulation in vitro when compared with patients with stable angina and controls. (5) Recombinant CD40L and serum from patients with unstable angina who had high sCD40L levels induced enhanced release of monocyte chemoattractant peptide-1 from mononuclear cells, a CC-chemokine involved in the pathogenesis of atherosclerosis. Conclusions-This first demonstration of enhanced levels of soluble and membrane-bound forms of CD40L in angina patients, with particularly high levels in patients with unstable angina, suggests that CD40L-CD40 interaction may play a pathogenic role in both the long-term atherosclerotic process and in the triggering and propagation of acute coronary syndromes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 14:20:37