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Titolo:
Recently activated T cells are costimulation-dependent in vitro
Autore:
Marelli-Berg, FM; Barroso-Herrera, O; Lechler, RI;
Indirizzi:
Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, Sch Med, Dept Immunol, London W12 0NN, England Univ London Imperial Coll Sci Technol &Med London England W12 0NN gland
Titolo Testata:
CELLULAR IMMUNOLOGY
fascicolo: 1, volume: 195, anno: 1999,
pagine: 18 - 27
SICI:
0008-8749(19990710)195:1<18:RATCAC>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
THYROID FOLLICULAR CELLS; ANTIGEN PRESENTATION; INTERFERON-GAMMA; MONOCLONAL-ANTIBODY; DENDRITIC CELLS; TOLERANCE; INDUCTION; HYPORESPONSIVENESS; UNRESPONSIVENESS; RECOGNITION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Marelli-Berg, FM Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, Sch Med, Dept Immunol, London W12 0NN, England Univ London Imperial Coll Sci Technol & Med London England W12 0NN
Citazione:
F.M. Marelli-Berg et al., "Recently activated T cells are costimulation-dependent in vitro", CELL IMMUN, 195(1), 1999, pp. 18-27

Abstract

While the prominent role of B7-mediated signaling in the activation of naive and resting T cells has been exhaustively demonstrated, it is unclear whether costimulation is required in the amplification of an initiated immuneresponse. In this study we have developed a multistep culture system to investigate the costimulation requirements of recently activated alloreactiveCD4(+) T cells and the outcome of allorecognition of B7-deficient, MHC class-II-expressing epithelial cells. The results show that following in vitro"priming" with allogeneic costimulation rich antigen presenting cells, T cells can be reactivated 60 proliferate only if B7-mediated costimulation isprovided. Furthermore, recognition of antigen on B7-negative epithelial cells induced allospecific nonresponsiveness in the responder T cells. Finally, the nonresponsive state was not accompanied by IL-4 secretion and appeared to be reversible, since T cell reactivity could be restored by short-term culture in the presence of IL-2. These observations suggest that "primed"T cells remain B7-dependent in vitro and are susceptible to functional inactivation following costimulation-deficient antigen presentation. (C) 1999 Academic Press.

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Documento generato il 22/09/20 alle ore 23:41:38