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Titolo:
L-Arginine and L-NAME have no effects on the reendothelialization process after arterial balloon injury
Autore:
Six, I; Van Belle, E; Bordet, R; Corseaux, D; Callebert, J; Dupuis, B; Bauters, C; Bertrand, ME;
Indirizzi:
Univ Lille, Dept Pharmacol, F-59037 Lille, France Univ Lille Lille France F-59037 e, Dept Pharmacol, F-59037 Lille, France Univ Lille, Dept Cardiol, F-59037 Lille, France Univ Lille Lille France F-59037 lle, Dept Cardiol, F-59037 Lille, France Hop Lariboisiere, Dept Biochem, F-75010 Paris, France Hop Lariboisiere Paris France F-75010 ept Biochem, F-75010 Paris, France
Titolo Testata:
CARDIOVASCULAR RESEARCH
fascicolo: 3, volume: 43, anno: 1999,
pagine: 731 - 738
SICI:
0008-6363(19990815)43:3<731:LALHNE>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIBROBLAST GROWTH-FACTOR; RABBIT THORACIC AORTA; ENDOTHELIAL-CELLS; HYPERCHOLESTEROLEMIC RABBIT; INTIMAL HYPERPLASIA; SMOOTH-MUSCLE; IN-VIVO; ANGIOGENESIS; INHIBITION; PROLIFERATION;
Keywords:
experimental; vasculature; circulatory physiology arteries; endothelial factors; nitric oxide; angioplasty;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Bauters, C Hop Cardiol, Serv Cardiol B, Blvd Prof J Leclercq, F-59037 Lille, France Hop Cardiol Blvd Prof J Leclercq Lille France F-59037 , France
Citazione:
I. Six et al., "L-Arginine and L-NAME have no effects on the reendothelialization process after arterial balloon injury", CARDIO RES, 43(3), 1999, pp. 731-738

Abstract

Objective: Growth regulatory properties of nitric oxide (NO) in cultured endothelial cells is controversial. The aim of our study was to investigate the effect of l-arginine, the endogenous NO precursor, and L-NAME, an inhibitor of NO synthase on the reendothelialization process after angioplasty. Methods: Fifty-five New Zealand White rabbits underwent denudation of the left iliac artery. After injury the rabbits were randomized in three groups:L-arginine 2.25% (l-arginine, n=19); N-G-nitro-L-arginine methyl ester 15 mg/kg/day (L-NAME, n=19); and placebo (controls, n=17). Treatment was solubilized in drinking water. Reendothelialization was evaluated at 4 weeks by macroscopic evaluation of Evens blue staining and endothelial-specific immunostaining (CD-31) on cross sections. Intimal hyperplasia was evaluated by morphometric analysis. Results: Despite a significant increase in plasma arginine (P=0.001) and a reduction in intimal hyperplasia (P=0.003) with L-arginine, neither agent had a significant effect on reendothelialization at 4weeks (controls=36+/-4%, L-arginine=43+/-3%, L-NAME=33+/-4%; NS). Conclusion: These results suggest that, in spite of previously demonstrated effectson neointimal hyperplasia, the NO pathway does not influence the regrowth of macrovascular endothelial cells in vivo. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 15:53:17