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Titolo:
Potential roles for p53 in nucleotide excision repair
Autore:
McKay, BC; Ljungman, M; Rainbow, AJ;
Indirizzi:
Univ Michigan, Dept Radiat Oncol, Div Canc Biol, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 rehens Canc, Ann Arbor, MI 48109 USA McMaster Univ, Dept Biol, Hamilton, ON L8S 4K1, Canada McMaster Univ Hamilton ON Canada L8S 4K1 ol, Hamilton, ON L8S 4K1, Canada
Titolo Testata:
CARCINOGENESIS
fascicolo: 8, volume: 20, anno: 1999,
pagine: 1389 - 1396
SICI:
0143-3334(199908)20:8<1389:PRFPIN>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSCRIPTION-COUPLED REPAIR; RNA-POLYMERASE-II; CYCLOBUTANE PYRIMIDINE DIMERS; LI-FRAUMENI SYNDROME; WILD-TYPE P53; IRRADIATED HUMAN FIBROBLASTS; XERODERMA PIGMENTOSUM-CELLS; HUMAN OSTEOSARCOMA CELLS; COMPLEMENTATION GROUP-C; COCKAYNE-SYNDROME CELLS;
Tipo documento:
Editorial Material
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
95
Recensione:
Indirizzi per estratti:
Indirizzo: McKay, BC Univ Michigan, Dept Radiat Oncol, Div Canc Biol, Ctr Comprehens Canc, 1500E Med Ctr Dr, Ann Arbor, MI 48109 USA Univ Michigan 1500 E Med Ctr Dr Ann Arbor MI USA 48109 48109 USA
Citazione:
B.C. McKay et al., "Potential roles for p53 in nucleotide excision repair", CARCINOGENE, 20(8), 1999, pp. 1389-1396

Abstract

Ultraviolet (UV) light-induced DIVA damage is repaired by the nucleotide excision repair pathway, which can be subdivided into transcription-coupled repair (TCR) and global genome repair (GGR), Treatment of cells with a priming dose of UV light appears to stimulate both GGR and TCR, suggesting thatthese processes are inducible. GGR appears to be disrupted in p53-deficient fibroblasts, whereas the effect of p53 disruption on TCR remains somewhatcontroversial. Normal recovery of mRNA synthesis following UV irradiation is thought to depend on TCR, We have found that the recovery of mRNA synthesis following exposure to UV light is severely attenuated in p53-deficient human fibroblasts. Therefore, p53 disruption may lead to a defect in TCR ora post-repair process required for the recovery of mRNA synthesis. Severaldifferent functions of p53 have been proposed which could contribute to these cellular processes. We suggest that p53 could participate in GGR and the recovery of mRNA synthesis following UV exposure through the regulation of steady-state levels of one or more p53-regulated gene products important for these processes. Furthermore, we suggest that the role of p53 in the recovery of mRNA synthesis is important for resistance to UV-induced apoptosis.

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Documento generato il 27/11/20 alle ore 13:42:17