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Titolo:
Brainstem triggers absence seizures in human generalized epilepsy
Autore:
Kohsaka, S; Mizukami, S; Uetake, K; Sakai, T; Kohsaka, M;
Indirizzi:
Hokkaido Univ, Sch Med, Dept Pediat, Kita Ku, Sapporo, Hokkaido 060, JapanHokkaido Univ Sapporo Hokkaido Japan 060 Ku, Sapporo, Hokkaido 060, Japan Sapporo Hanazono Hosp, Sapporo, Hokkaido 064, Japan Sapporo Hanazono HospSapporo Hokkaido Japan 064 oro, Hokkaido 064, Japan
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1-2, volume: 837, anno: 1999,
pagine: 277 - 288
SICI:
0006-8993(19990807)837:1-2<277:BTASIH>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
PENICILLIN EPILEPSY; WAVE DISCHARGES; SPIKE; POTENTIALS; TRANSITION; CAT; PROJECTIONS; COMPONENTS; THALAMUS; SPINDLES;
Keywords:
absence seizure; primary generalized epilepsy; brainstem auditory evoked potential; simultaneous analysis; lower brainstem; centrencephalic system;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Kohsaka, S Hokkaido Univ, Sch Med, Dept Pediat, Kita Ku, N15 W7, Sapporo, Hokkaido 060, Japan Hokkaido Univ N15 W7 Sapporo Hokkaido Japan 060 aido 060, Japan
Citazione:
S. Kohsaka et al., "Brainstem triggers absence seizures in human generalized epilepsy", BRAIN RES, 837(1-2), 1999, pp. 277-288

Abstract

Simultaneous analysis of brainstem auditory evoked potentials (BAEPs) withreference to electroencephalography (EEG) was designed to examine the brainstem function corresponding to the EEG event. With this method, we investigated the brainstem function pre- and during the paroxysmal discharge in human absence seizures classified as primary generalized epilepsy (PGE). Two types of functional change in the lower brainstem were revealed as parameters of wave-III components (amplitude and area) of BAEPs without significantchange in the upper brainstem. One was long-range biphasic fluctuation (acceleration followed by abrupt deceleration with the maximum -6.4 +/- 3.2 s before the seizure onset), and the other was rhythmic oscillation with 3 Hz. The latter, synchronized with the cortical spike-and-wave complex, imposed on the descending slope of the former. One important point is that both preceded the onset of cortical paroxysmal discharge. The results reappraise the classical hypothesis of "centrencephalic system" on seizure generating mechanism in human PGE. The results prove the primary triggering role of the lower brainstem that is independent of sleep-related synchronizations. The method is applicable to other types of EEG event for the investigation ofbrainstem involvement. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 09:03:04