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Titolo:
Does maternal stress induce abnormal descent of the testis in prepubertal rats?
Autore:
Shono, T; Imajima, T; Zakaria, O; Suita, S;
Indirizzi:
Kyushu Univ, Fac Med, Dept Paediat Surg, Higashi Ku, Fukuoka 81282, Japan Kyushu Univ Fukuoka Japan 81282 t Surg, Higashi Ku, Fukuoka 81282, Japan
Titolo Testata:
BJU INTERNATIONAL
fascicolo: 3, volume: 84, anno: 1999,
pagine: 353 - 356
SICI:
1464-4096(199908)84:3<353:DMSIAD>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEXUALLY DIMORPHIC NUCLEI; TESTICULAR DESCENT; SPINAL-CORD; FLUTAMIDE; TESTOSTERONE; RELEASE; FETAL;
Keywords:
maternal stress; undescended testis; rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Shono, T Kyushu Univ, Fac Med, Dept Paediat Surg, Higashi Ku, Maidashi 3-1-1, Fukuoka 81282, Japan Kyushu Univ Maidashi 3-1-1 Fukuoka Japan 81282 uoka 81282, Japan
Citazione:
T. Shono et al., "Does maternal stress induce abnormal descent of the testis in prepubertal rats?", BJU INT, 84(3), 1999, pp. 353-356

Abstract

Objective To investigate whether prenatal maternal stress, considered to alter plasma testosterone concentration and induce a lack of testosterone surge in male rat fetuses, has any effect on the growth of the processus vaginalis and testicular descent in male offspring. Materials and methods Pregnant rats were divided into two groups. In group1, the rats were placed three times daily for 60 min each session in Plexiglas rat holders (13 x 6 x 8 cm) illuminated by two 150-W flood lights fromday 14 to day 18 of gestation during the dark phase of the animals' light (12 h) and dark (12 h) cycle. In group 2, pregnant females were not handledand acted as controls. After birth, the anogenital distance of both the male and female rats was measured, and the length of the processus vaginalis was measured at 7 days of age in some rats. Thereafter, at 21, 24, 27 and 30 days of age, testicular descent was assessed in the remaining male rats. Results In group 1, at 21, 24, 27 days of age, testicular descent was delayed in the stressed rats compared with the control rats. At 30 days of age,five of 36 stressed male offspring showed abnormal testicular descent; three testes were in the superficial inguinal position and two were above the scrotum. Both the anogenital distance and the length of the processus vaginalis were significantly less in the stressed male rats than in the controls. Conclusions Maternal stress induced a female-like anogenital distance in male rat fetuses, and caused delayed and abnormal descent of the test is, byinhibiting the growth of the processus vaginalis after birth. Prenatal stress may therefore be involved in the delay of testicular descent in neonatal rats by inducing a mild anti-androgenic effect in the fetus.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 01:01:59