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Titolo:
3-alkyl-(5,5 '-diphenyl)imidazolidinediones as new cannabinoid receptor ligands
Autore:
Kanyonyo, M; Govaerts, SJ; Hermans, E; Poupaert, JH; Lambert, DM;
Indirizzi:
Univ Catholique Louvain, Unite Chim Pharmaceut & Radiopharm, B-1200 Brussels, Belgium Univ Catholique Louvain Brussels Belgium B-1200 B-1200 Brussels, Belgium Univ Catholique Louvain, Unite Chim Pharmaceut & Radiopharm, B-1200 Brussels, Belgium Univ Catholique Louvain Brussels Belgium B-1200 B-1200 Brussels, Belgium
Titolo Testata:
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
fascicolo: 15, volume: 9, anno: 1999,
pagine: 2233 - 2236
SICI:
0960-894X(19990802)9:15<2233:3'ANCR>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
SELECTIVE ANTAGONIST; INVERSE AGONIST; CB1 RECEPTOR; POTENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Lambert, DM Univ Catholique Louvain, Unite Chim Pharmaceut & Radiopharm, Ave E Mounier73-40, B-1200 Brussels, Belgium Univ Catholique Louvain Ave E Mounier 73-40 Brussels Belgium B-1200
Citazione:
M. Kanyonyo et al., "3-alkyl-(5,5 '-diphenyl)imidazolidinediones as new cannabinoid receptor ligands", BIOORG MED, 9(15), 1999, pp. 2233-2236

Abstract

Twenty-four 3-alkyl-(5,5'-diphenyl)imidazolidinediones were synthesized and evaluated as new cannabinoid receptor ligands. Three compounds exhibited a Ki value around 100 nM against [H-3]-SR 141716A binding obtained from human CB1 transfected CHO cells membranes. The lack of change of affinity in the presence of a non hydrolyzable GTP analogue seems to indicate they are cannabinoid antagonists. (C) 1999 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 06:17:15