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Titolo:
INFLUENCE OF ACINAR TISSUE CONTAMINATION ON ENCAPSULATED PANCREATIC-ISLETS - MORPHOLOGICAL AND FUNCTIONAL-STUDIES
Autore:
KESSLER L; JESSER C; BELCOURT A; PINGET M;
Indirizzi:
HOP UNIV STRASBOURG,SERV ENDOCRINOL,JEUNE EQUIPE MED,PAVILLON LERICHEF-67091 STRASBOURG FRANCE UNIV STRASBOURG 1,FAC MED,CTR EUROPEEN ETUD DIABET STRASBOURG FRANCE
Titolo Testata:
Transplantation
fascicolo: 10, volume: 63, anno: 1997,
pagine: 1537 - 1540
SICI:
0041-1337(1997)63:10<1537:IOATCO>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSPLANTATION; INSULIN; MATRIX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
10
Recensione:
Indirizzi per estratti:
Citazione:
L. Kessler et al., "INFLUENCE OF ACINAR TISSUE CONTAMINATION ON ENCAPSULATED PANCREATIC-ISLETS - MORPHOLOGICAL AND FUNCTIONAL-STUDIES", Transplantation, 63(10), 1997, pp. 1537-1540

Abstract

Background. The present study concerns the influence of acinar contamination on pancreatic islets encapsulated in an artificial membrane (AN 69). Methods. Pure, handpicked pancreatic islets were contaminated by the addition of acinar tissue (ratio, 1:1). The morphological aspectand insulin release of both pure (n=12) and contaminated (n=12) encapsulated islets were assessed after 10 days of culture or implantation in the peritoneal cavity of rats. Results. After implantation, the encapsulated islets, irrespective of their purity, were totally altered, whereas the morphological aspect of the cultivated isIets remained intact only in the absence of acinar tissue contamination. This contamination induced a significant decrease in the stimulation index of insulin release. The stimulation index decreased by 42% for fresh islets andby 52% and 34% for cultivated and implanted islets, respectively, without modification in their basal release of insulin. Conclusions. The acinar tissue proved detrimental to the encapsulated implanted and cultivated islets.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 02:58:15