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Titolo:
Inhibition of experimental bone resorption and osteoclast formation and survival by 2-aminoethanesulphonic acid
Autore:
Koide, M; Okahashi, N; Tanaka, R; Kazuno, K; Shibasaki, K; Yamazaki, Y; Kaneko, K; Ueda, N; Ohguchi, M; Ishihara, Y; Noguchi, T; Nishihara, T;
Indirizzi:
Natl Inst Infect Dis, Dept Oral Sci, Shinjuku Ku, Tokyo 1628640, Japan Natl Inst Infect Dis Tokyo Japan 1628640 injuku Ku, Tokyo 1628640, Japan Aichi Gakuin Univ, Sch Dent, Dept Periodontol, Chikusa Ku, Nagoya, Aichi 4648651, Japan Aichi Gakuin Univ Nagoya Aichi Japan 4648651 Nagoya, Aichi 4648651, Japan Lion Corp, Oral Care Res Labs, Odawara, Kanagawa 2560811, Japan Lion CorpOdawara Kanagawa Japan 2560811 Odawara, Kanagawa 2560811, Japan
Titolo Testata:
ARCHIVES OF ORAL BIOLOGY
fascicolo: 9, volume: 44, anno: 1999,
pagine: 711 - 719
SICI:
0003-9969(199909)44:9<711:IOEBRA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTINOBACILLUS-ACTINOMYCETEMCOMITANS; BACTEROIDES-GINGIVALIS; CELL-FORMATION; MARROW CULTURES; TISSUE-CULTURE; TAURINE; LIPOPOLYSACCHARIDE; DIFFERENTIATION; INTERLEUKIN-1; PROSTAGLANDIN;
Keywords:
Actinobacillus actinomycetemcomitans; bone resorption; 2-aminoethanesulphonic acid; osteoclasts; periodontitis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Nishihara, T Natl Inst Infect Dis, Dept Oral Sci, Shinjuku Ku, 1-23-1 Toyama, Tokyo 1628640, Japan Natl Inst Infect Dis 1-23-1 Toyama Tokyo Japan 1628640 Japan
Citazione:
M. Koide et al., "Inhibition of experimental bone resorption and osteoclast formation and survival by 2-aminoethanesulphonic acid", ARCH ORAL B, 44(9), 1999, pp. 711-719

Abstract

It is known that bone resorption is mediated by osteoclasts, and lipopolysaccharide (LPS) and inflammatory mediators such as interleukin-1 (IL-1) andprostaglandin E-2 (PGE(2)) induce osteoclast differentiation from haemopoietic cells, 2-aminoethanesulphonic acid, which is known as taurine, is an important nutrient and is added to most synthetic human infant milk formulas. In this study, it was found that 2-aminoethanesulphonic acid inhibits thestimulation of bone resorption mediated by LPS of the periodontopathic microorganism Actinobacillus actinomycetemcomitans Y4 in organ cultures of newborn mouse calvaria. The effect of 2-aminoethanesulphonic acid on the development and survival of osteoclast-like multinucleated cells produced in a mouse bone-marrow culture system was also examined. 2-aminoethanesulphonic acid (100 mu g/ml) suppressed the formation of these osteoclastlike cells inthe presence of LPS of A. actinomycetemcomitans Y4, IL-1 alpha or PGE(2) in mouse marrow cultures. On the other hand, 2-aminoethanesulphonic acid didnot inhibit 1 alpha, 25-dihydroxyvitamin D-3-mediated osteoclast differentiation. Although IL-1 alpha elongated the survival of the osteoclast-like cells, 2-aminoethanesulphonic acid blocked the supportive effect of IL-1 alpha on osteoclast survival. 2-aminoethanesulphonic acid showed no effect on the growth of mouse osteoblasts. Finally, it was found that 2-aminoethanesulphonic acid inhibited alveolar bone resorption in experimental periodontitis in hamsters. These results suggest that 2-aminoethanesulphonic acid is an effective agent in preventing inflammatory bone resorption in periodontaldiseases. (C) 1999 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:45:04