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Titolo:
Immunohistochemical detection of matrix metalloproteinases (MMP) 1 and 2, and tissue inhibitor of metalloproteinase 2 (TIMP 2) in stage I and II endometrial cancer
Autore:
Moser, PL; Hefler, L; Tempfer, C; Neunteufel, W; Kieback, DG; Gitsch, G;
Indirizzi:
Univ Freiburg, Med Ctr, Dept Gynecol & Obstet, D-79106 Freiburg, Germany Univ Freiburg Freiburg Germany D-79106 Obstet, D-79106 Freiburg, Germany Innsbruck Univ, Dept Pathol, A-6020 Innsbruck, Austria Innsbruck Univ Innsbruck Austria A-6020 athol, A-6020 Innsbruck, Austria Univ Vienna, Dept Obstet & Gynecol, Vienna, Austria Univ Vienna Vienna Austria enna, Dept Obstet & Gynecol, Vienna, Austria Hosp Dornbirn, Dept Obstet & Gynecol, Dornbirn, Austria Hosp Dornbirn Dornbirn Austria Dept Obstet & Gynecol, Dornbirn, Austria
Titolo Testata:
ANTICANCER RESEARCH
fascicolo: 3B, volume: 19, anno: 1999,
pagine: 2365 - 2367
SICI:
0250-7005(199905/06)19:3B<2365:IDOMM(>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPRESSION; CARCINOMA;
Keywords:
metalloproteinases; endometrial cancer; immunohistochemistry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Gitsch, G Univ Freiburg, Med Ctr, Dept Gynecol & Obstet, Hugstetter Str 55, D-79106 Freiburg, Germany Univ Freiburg Hugstetter Str 55 Freiburg Germany D-79106 ermany
Citazione:
P.L. Moser et al., "Immunohistochemical detection of matrix metalloproteinases (MMP) 1 and 2, and tissue inhibitor of metalloproteinase 2 (TIMP 2) in stage I and II endometrial cancer", ANTICANC R, 19(3B), 1999, pp. 2365-2367

Abstract

Background: Matrix metalloproteinases (MMPs) are a family of zinc-dependent metalloendopeptidases which participate in the degradation of collagen and other extracellular matrix macromolecules. Expression of gelatonic MMPs, such as MMP- 2 has been linked to enhanced tumor invasion and metastasis inin vitro and in vivo model systems. If was the aim of this study to determine whether the expression of MMP-1, MMP-2, and TIMP-2 correlates with survival in patients with surgically treated endometrial cancer. Metod: A sample of 103 paraffin-embedded tumor specimens of surgical treated endometrial cancer was immunohistochemically investigated. Results: MMP-1, MMP-2, and TIMP-2 were detected by immunohistochemistry in 95% (98/103), 87% (89/103), and 80% (82/103) of the tumour samples, respectively. Correlation coefficients for MMP-1/MMP-2 MMP-1/TIMP-2 MMP- 2/TIMP-2 were 0.28 (p=0.004), 0.05 (p=0.6), and -0.03 (p=0.73), respectively. In the univariate analysis, the expression of MMP-1 (log-rank test, p=ns), MMP-2 (log-rank test, p=ns), and TIMP-2 (log-rank test, p=ns) were not associated with overall survival. Conclusinn: MMP-1, MMP-2, and TIMP-2, detected by immunohistochemistry are not helpful in predicting the prognosis of endometrial cancer patients.

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Documento generato il 07/07/20 alle ore 06:14:36