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Titolo:
Neurofilament is an autoantigenic determinant in myasthenia gravis
Autore:
Schultz, A; Hoffacker, V; Wilisch, A; Nix, W; Gold, R; Schalke, B; Tzartos, S; Muller-Hermelink, HK; Marx, A;
Indirizzi:
Univ Wurzburg, Inst Pathol, D-97080 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97080 Pathol, D-97080 Wurzburg, Germany Univ Wurzburg, Dept Neurol, D-97080 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97080 Neurol, D-97080 Wurzburg, Germany Univ Mainz, Neurol Inst, D-6500 Mainz, Germany Univ Mainz Mainz Germany D-6500 ainz, Neurol Inst, D-6500 Mainz, Germany Univ Regensburg, Dept Neurol, D-8400 Regensburg, Germany Univ Regensburg Regensburg Germany D-8400 ol, D-8400 Regensburg, Germany Hellen Pasteur Inst, Athens, Greece Hellen Pasteur Inst Athens GreeceHellen Pasteur Inst, Athens, Greece
Titolo Testata:
ANNALS OF NEUROLOGY
fascicolo: 2, volume: 46, anno: 1999,
pagine: 167 - 175
SICI:
0364-5134(199908)46:2<167:NIAADI>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
THYMIC EPITHELIAL TUMORS; ACETYLCHOLINE-RECEPTOR EPITOPES; T-CELLS; SELF-PEPTIDES; ALPHA-SUBUNIT; THYMOMAS; PATHOGENESIS; LYMPHOCYTES; REPERTOIRE; AUTOANTIBODIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Marx, A Univ Wurzburg, Luitpoldkrankenhaus, Inst Pathol, Josef Schneider Str 2, D-97080 Wurzburg, Germany Univ Wurzburg Josef Schneider Str 2 Wurzburg Germany D-97080 many
Citazione:
A. Schultz et al., "Neurofilament is an autoantigenic determinant in myasthenia gravis", ANN NEUROL, 46(2), 1999, pp. 167-175

Abstract

Intratumorous expression of a 153-kd protein (p153), which contains an acetylcholine receptor-like epitope, is the only tumor marker described to date that significantly associates with thymoma in paraneoplastic myasthenia gravis (MG). Here, we report that p153 is identical to the midsize neurofilament, as verified by immunohistochemistry, immunofluorescence, and western blot analysis. Furthermore, the acetylcholine receptor-like epitope of the midsize neurofilament (NF-M) was identified by peptide epitope mapping. We also show, using T-cell proliferation assays, a significantly increased response of intratumorous T cells to a recombinant midsize neurofilament fragment in thymoma patients with MG compared with MG patients with thymic follicular hyperplasia or thymoma patients without MG. The T cells of thymic follicular hyperplasia and thymoma patients without MG seem to be unresponsiveto NF-M. In contrast, we found increased T-cell responses to recombinant acetylcholine receptor fragments in MG patients in general compared with non-MG patients. Increased T-cell responses to NF-M in patients with paraneoplastic MG might be the result of an abnormal positive selection of immature T cells within thymomas, caused by the expression of NF-M in neoplastic thymic epithelial cells. Our results offer further evidence that NF-M expression in thymomas is an autoantigenic determinant in MG.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 20:02:53