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Titolo:
RENAL EXPRESSION OF MONOCYTE CHEMOATTRACTANT PROTEIN-1 IN LUPUS AUTOIMMUNE MICE
Autore:
ZOJA C; LIU XH; DONADELLI R; ABBATE M; TESTA D; CORNA D; TARABOLETTI G; VECCHI A; DONG QG; ROLLINS BJ; BERTANI T; REMUZZI G;
Indirizzi:
MARIO NEGRI INST PHARMACOL RES,VIA GAVAZZENI 11 I-24125 BERGAMO ITALY OSPED RIUNITI BERGAMO,DIV NEPHROL & DIALYSIS I-24100 BERGAMO ITALY DANA FARBER CANC INST,DEPT MED BOSTON MA 02115
Titolo Testata:
Journal of the American Society of Nephrology
fascicolo: 5, volume: 8, anno: 1997,
pagine: 720 - 729
SICI:
1046-6673(1997)8:5<720:REOMCP>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; HUMAN MESANGIAL CELLS; BLOOD MONONUCLEAR LEUKOCYTES; GLOMERULAR ENDOTHELIAL-CELLS; GENE-EXPRESSION; EXPERIMENTAL GLOMERULONEPHRITIS; CHEMOTACTIC PROTEIN-1; KAPPA-B; MCP-1; NEPHRITIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
56
Recensione:
Indirizzi per estratti:
Citazione:
C. Zoja et al., "RENAL EXPRESSION OF MONOCYTE CHEMOATTRACTANT PROTEIN-1 IN LUPUS AUTOIMMUNE MICE", Journal of the American Society of Nephrology, 8(5), 1997, pp. 720-729

Abstract

Mononuclear cell infiltration in glomeruli and renal interstitium is a prominent feature of some types of glomerulonephritis, including lupus nephritis. The mechanism(s) underlying monocyte influx into the kidney is not fully understood. Recently, monocyte chemoattractant protein-1 (MCP-1) has been identified as a chemotactic factor involved in the recruitment of monocytes/macrophages in the glomeruli of rats with mesangioproliferative as well as anti-glomerular basement membrane glomerulonephritis. In the study presented here, renal MCP-1 mRNA expression in New Zealand Black x New Zealand White (NZB/W) F1 mice, a model of genetically determined immune complex disease that mimics systemic lupus in humans, was investigated. Northern blot analysis revealed a single 0.7 kb MCP-1 transcript of very low intensity in kidneys from 2-month-old NZB/W mice that had not yet developed proteinuria nor renal damage. Message levels, which increased markedly with the progression of nephritis and in association with mononuclear cell infiltration, were 10- and 15- fold higher in 8-10-month-old mice than in 2-month-old mice. By in situ hybridization, increased expression of MCP-1 mRNA was demonstrated in glomeruli and, even more striking, in tubular epithelial cells. Western blot analysis demonstrated increased expression of MCP-1 protein in kidneys of 10-month-old NZB/W mice, consistent with MCP-1 mRNA data. When NZB/W mice were treated with cyclophosphamide up to 12 months of age, expression of MCP-1 in the renal tissue remained low, the influx of inflammatory cells did not appear, and glomerular and tubular structures remained well preserved. These data suggest that elevated MCP-1 might act as a signal for inflammatory cells to infiltrate the kidney in lupus nephritis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 00:31:24